| 含La医用316L不锈钢的体外抗凝血性能研究 |
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| 引用本文： | 杨化娟,杨柯,张炳春.含La医用316L不锈钢的体外抗凝血性能研究[J].金属学报,2006,42(9):959-964. |
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| 作者姓名： | 杨化娟 杨柯 张炳春 |
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| 作者单位： | 1. 中国科学院金属研究所,沈阳,110016;中国科学院研究生院,北京,100039
2. 中国科学院金属研究所,沈阳,110016 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 系统研究了在医用316L不锈钢中加入0．05％La后的体外抗凝血性能．结果表明，与传统医用316L不锈钢相比，含La医用316L不锈钢较少地粘附和激活血小板，且动态凝血时间及血浆复钙时间均延长，表明其对内源性凝血因子的激活程度下降，抗凝血性能提高．通过测量材料的接触角，计算了表面张力及材料与血液之间的界面张力，从表面能的角度分析了材料的抗凝血机理．
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| 关 键 词： | 医用316L不锈钢 抗凝血 表面能 |
| 文章编号： | 0412-1961（2006）09-0959-06 |
| 收稿时间： | 2006-01-04 |
| 修稿时间： | 2006-01-042006-04-18 |
STUDY OF IN VITRO ANTICOAGULANT PROPERTY OF THE La ADDED MEDICAL 316L STAINLESS STEEL |
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| YANG Huajuan,YANG Ke,ZHANG Bingchun.STUDY OF IN VITRO ANTICOAGULANT PROPERTY OF THE La ADDED MEDICAL 316L STAINLESS STEEL[J].Acta Metallurgica Sinica,2006,42(9):959-964. |
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| Authors: | YANG Huajuan YANG Ke ZHANG Bingchun |
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| Affiliation: | 1. Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016;2. Graduate School of the Chinese Academy of Sciences, Beijing 100039 |
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| Abstract: | The in vitro anticoagulant property of a medical grade 316L stainless steel with 0.05% La addition was systematically studied. The results showed that, compared with the conventionally used medical 316L stainless steel, the La added 316L steel possesses less platelets adhesion and less activation of the platelets, and their kinetic clotting time and the plasma recalcification time become longer, which reveals that the activation extent of the latter on intrinsic coagulation factors is smaller than the former and the anticoagulant property of the latter is better. Through measurement of the contact angles of the steels, and calculations of the surface tension of the steels and the interfacial tension between the steels and the blood, the anticoagulant mechanism of the steels was analyzed from the viewpoint of surface energy. |
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| Keywords: | La |
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