抑郁症相关离子通道研究进展

抑郁症是以情绪、认知、神经内分泌和躯体功能障碍为特征的中枢系统神经疾病，是最常见的精神疾病之一。目前，抗抑郁药的治疗机制主要是以增加脑内5-羟色胺、去甲肾上腺素和多巴胺等单胺递质的浓度为主，但抑郁症仍没有得到充分的治疗。本文以离子通道为切入点，对目前研究较多的与抑郁症相关的电压门控性离子通道（如钠离子、钾离子和钙离子等）和配体门控性离子通道（如谷氨酸受体、γ-氨基丁酸受体和5-羟色胺受体等）分别予以综述，以期为抗抑郁新药的开发提供新思路。

Advances of the ion channels related to depression

Depression is a central nervous system disorder characterized by emotion, cognition, neuroendocrine and somatic dysfunction, and is one of the most common mental diseases. Currently, the treatment mechanism of antidepressants mainly focuses on the concentrations of monoamine neurotransmitters in the brain such as serotonin, norepinephrine and dopamine, but depression is still not fully treated. In this paper, the ion channel as the starting point, the depression-related voltage-gated ion channels (such as sodium, potassium and calcium ions, etc.) and ligand-gated ion channels (such as glutamic acid receptor, γ-aminobutyric acid receptor and serotonin receptor, etc.) were reviewed respectively, to provide new ideas for the development of new antidepressants.