| 胃癌靶向治疗药物临床实验研究进展 |
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| 引用本文： | 帕孜来提·亚森,袁浩,路红,郑亚,王玉平,周永宁.胃癌靶向治疗药物临床实验研究进展[J].金属学报,2021,26(4):454-461. |
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| 作者姓名： | 帕孜来提·亚森 袁浩 路红 郑亚 王玉平 周永宁 |
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| 作者单位： | 1.兰州大学 第一临床医学院，兰州 730000，甘肃；;2.兰州大学第一医院 消化科，兰州 730000，甘肃；;3.兰州大学第一医院 甘肃省胃肠病重点实验室，兰州 730000，甘肃 |
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| 基金项目： | 国家自然科学基金（81960430）；国家重点研发计划（2016YFC1302201）；兰州大学中央高校基本科研业务费专项资金（lzujbky-2020-kb16） |
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| 摘 要： | 以往针对进展期胃癌进行化疗常作为其最佳治疗选择，但传统化疗不良反应大，耐药率高，成为治疗难点。近年来，分子靶向药物具有可选择性杀伤肿瘤细胞、药物不良反应小等优点，成为临床研究热点。以受体酪氨酸激酶为靶点的靶向药物联合化疗药物治疗胃癌的多项临床试验证实联合疗法可带来生存效益，将是胃癌治疗的有效手段。本文就胃癌靶向治疗药物临床实验研究进展进行综述。
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| 收稿时间： | 2020-11-17 |
| 修稿时间： | 2021-01-04 |
Research progress in clinical trials of targeted drugs for gastric cancer |
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| Pazilaiti YASEN,YUAN Hao,LU Hong,ZHENG Ya,WANG Yuping,ZHOU Yongning.Research progress in clinical trials of targeted drugs for gastric cancer[J].Acta Metallurgica Sinica,2021,26(4):454-461. |
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| Authors: | Pazilaiti YASEN YUAN Hao LU Hong ZHENG Ya WANG Yuping ZHOU Yongning |
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| Affiliation: | 1. First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu, China;2. Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China;3.Key Laboratory for Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China |
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| Abstract: | In the past several years, chemotherapy, as the best treatment option for advanced gastric cancer, however, was associated with adverse events and high resistance rates. Recently, molecular targeted drugs have gradually come into notice of clinical researchers due to the advantages of selectively killing tumor cells and less adverse events. Many clinical trials have confirmed targeted drugs targeting receptor tyrosine kinases combined with chemotherapy drugs could provide more survival benefits and might be effective for the treatment of gastric cancer. This article aims to demonstrate the progress in clinical trials of targeted therapeutic drugs for gastric cancer. |
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| Keywords: | gastric cancer targeted therapeutic drugs clinical trials |
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