昼夜节律睡眠-觉醒障碍与恶性肿瘤发生发展的关系

昼夜节律睡眠-觉醒障碍是指睡眠-觉醒周期与人体24 h生物节律失调所致的一类睡眠疾病，它可以影响人体的认知功能和代谢等过程，还能促进恶性肿瘤的发生发展——通过改变时钟基因表达直接促进肿瘤增殖，并通过抑制褪黑素的分泌等内分泌机制间接加速肿瘤发展。本文阐述了昼夜节律睡眠-觉醒障碍的定义、它导致的病理状态以及它对恶性肿瘤发生发展的影响，以期为昼夜节律性睡眠-觉醒障碍影响的肿瘤发生发展的防治提供可能的治疗措施。

Relationship between circadian rhythm sleep-wake disorders and the development of malignant tumor

The circadian rhythm regulates many physiological processes of the human body. The circadian rhythm sleep-wake disorder refers to a type of disease caused by the mismatch of sleep-wake cycle and circadian rhythm. It affects the human body's cognitive function and metabolic processes. The circadian rhythm sleep-wake disorder also promotes the growth of malignant tumors, directly and indirectly, by changing the expression of clock genes and inhibiting the secretion of melatonin. This article discusses circadian rhythm sleep-wake disorders; the subgroups it includes, the pathological state it causes, and the relationship between it and the development of malignant tumor. We hope to provide possible treatment measures for tumors affected by circadian sleep-wake disorders.