| 2,6-二氨基-3,5-二硝基吡啶-1-氧化物的合成新方法 |
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| 引用本文： | 成健,姚其正,刘祖亮.2,6-二氨基-3,5-二硝基吡啶-1-氧化物的合成新方法[J].含能材料,2009,17(2):166-168. |
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| 作者姓名： | 成健 姚其正 刘祖亮 |
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| 作者单位： | 1. 南京理工大学化工学院,江苏,南京,210094
2. 中国药科大学药学院,江苏,南京,210094 |
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| 摘 要： | 以2,6-二氨基吡啶为起始原料,经酰基化、氮氧化、硝化、水解四步反应得到2,6-二氨基-3,5-二硝基吡啶-1-氧化物(ANPyO),总收率为81%.讨论了影响酰基化、氮氧化、硝化等反应的因素,用1H NMR, MS和红外光谱对ANPyO及其中间体结构进行了表征.该方法是对文献7]报道方法的进一步改进,提高了反应过程的安全性,后处理更加简单.
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| 关 键 词： | 有机化学 2 6-二氨基-3 5-二硝基吡啶-1-氧化物(ANPyO) 合成 新方法 |
| 收稿时间： | 2008/8/26 0:00:00 |
| 修稿时间： | 2008/10/23 0:00:00 |
Synthesis of 2,6-Diamino-3,5-dinitropyridine-1-oxide |
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| CHENG Jian,YAO Qi-zheng and LIU Zu-liang.Synthesis of 2,6-Diamino-3,5-dinitropyridine-1-oxide[J].Chinese Journal of Energetic Materials,2009,17(2):166-168. |
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| Authors: | CHENG Jian YAO Qi-zheng and LIU Zu-liang |
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| Affiliation: | 1.School of Chemical Engineering;Nanjing University of Science & Technology;Nanjing 210094;China;2.School of Pharmacy;China Pharmaceutical University;China |
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| Abstract: | 2,6-Diamino-3,5-dinitropyridine-1-oxide(ANPyO) was synthesized with 2,6-diaminopyridine as a starting material by acetylation,N-oxidation,nitration and hydrolysis steps in turn,and the yield of ANPyO was up to 81%.The main factors affecting the acetylation,N-oxidation and nitration were investigated,and the structures of intermediates and ANPyO were characterized by 1H NMR,MS and IR spectra. |
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| Keywords: | organic chemistry 2 6-diamino-3 5-dinitropyridine-1-oxide(ANPyO) synthesis novel synthetic method |
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