| 治疗用Na^131I胶囊的研制及其动物实验 |
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| 引用本文： | 陈大明,张瑞麟,杨红伟,郭红源,窦勤义,皮立新,张君丽,周新建,李方,吕京桥.治疗用Na^131I胶囊的研制及其动物实验[J].同位素,2001,14(2):81-86. |
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| 作者姓名： | 陈大明 张瑞麟 杨红伟 郭红源 窦勤义 皮立新 张君丽 周新建 李方 吕京桥 |
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| 作者单位： | 1. 中国原子能科学研究院同位素研究所,
2. 北京协和医院核医学科, |
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| 摘 要： | 本工作进行了治疗用Na
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| 关 键 词： | 治疗用Na^131I胶囊 吸附量 动物实验 甲亢 核素治疗 碘化钠胶囊 研制 |
| 文章编号： | 1000-7512(2001)02-0081-06 |
| 修稿时间： | 2000年11月16 |
Preparation and Animal
Experiments of Na131I Therapeutic Capsule |
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| CHEN Da-ming,ZHANG Rui-lin,YANG Hong-wei,GUO Hong-yuan,DOU Qin-yi,PI Li-xin,ZHANG Jun-li,ZHOU Xin-jian,LI Fang,LU Jing-qiao.Preparation and Animal
Experiments of Na131I Therapeutic Capsule[J].Isotopes,2001,14(2):81-86. |
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| Authors: | CHEN Da-ming ZHANG Rui-lin YANG Hong-wei GUO Hong-yuan DOU Qin-yi PI Li-xin ZHANG Jun-li ZHOU Xin-jian LI Fang LU Jing-qiao |
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| Abstract: | The preparation and property of Na131I therapeutic capsules are studied. The adsorption of different particle size Na2HPO4 with different crystallized water is investigated. The results indicate that the more the crystallized water, the less the adsorption; the small the particle size, the more the adsorption. The adsorbent amount of >110 mesh 500 mg anhydrous Na2HPO4 in No.0 capsule is 270 μL 0.05 mol/L NaOH solution. In order to prevent the volatility of radioiodide, 1% Vc should be included in adsorbent. The disintegrated time of capsule is 5 min. The radiochemical purity and nuclear purity of Na131I therapeutic capsule are over 95% and 99% respectively within 30 days after preparation. At the same time, the radioactivity of 20 capsules is in the range of 96.5%～103.5%. The animal experiments show that there is not extraordinary toxicity with Na131I therapeutic capsule, and no difference between Na131I therapeutic capsule and Na131I solution in rabbits thyroid uptake within 24 h. |
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