电子加速器生产医用同位素钼-99的发展现状与展望

99 Mo的衰变子体99m Tc是核医学领域中应用最广泛的放射性同位素,近年全球主要的99 Mo生产堆面临着非计划检修及关停退役等问题,导致其供应不稳定,因此多个发达国家已在积极开发99 Mo生产的替代性技术.本文介绍了多种利用粒子加速器代替反应堆生产99 Mo的技术路线,总结了电子加速器生产99 Mo的国内外研究进展...

Development Status and Prospect for the Medical Isotope Molybdenum-99 Produced by Electron Accelerator

As the decay daughter of ⁹⁹Mo, ^99mTc is the most widely used radioisotope in the field of nuclear medicine. Recently, the major ⁹⁹Mo production reactors in the world are facing problems such as unplanned maintenance, shutdown and decommission, resulting in the unstable supply of ⁹⁹Mo. Therefore, many developed countries have been actively exploiting alternative technologies for ⁹⁹Mo production. In this paper, various ⁹⁹Mo-production technologies by particle accelerator instead of reactor were introduced, and the research progress of producing ⁹⁹Mo based on electron accelerator was summarized at home and abroad. The accelerator performance index and the key technologies in the production process were discussed in detail, such as the design of irradiation device and target, separation of ^99mTc, recovery of ¹⁰⁰Mo and waste management. In addition, some suggestions were put forward for the basic and applied research of relevant technologies in China and the commercialization of ⁹⁹Mo production by electron accelerator.