液闪法研究63Ni-NiCl2在大鼠体内的吸收、分布及排泄

采用液体闪烁计数法研究了63Ni-NiCl2在大白鼠体内的吸收、分布以及排泄。结果显示:63Ni-NiCl2在大白鼠体内的血药时间-浓度曲线符合二房室开放模型,吸收速率常数Ka=6.18/h,分布相半衰期T1/2(α)=0.79 h,消除相半衰期T1/2(β)=40.68 h,清除速率常数CL=0.42 mL.kg-1.h-1,达峰时间Tpeak=0.53h,达峰浓度Cmax=14.99 GBq/L,表观容积分布Vd=0.016 L/kg;在所测的12种组织中均有63Ni-NiCl2放射性摄取;在灌胃0.25 h时,肠、胃、腹膜后脂肪放射性摄取较高,3 h时,肠、胃、肝放射性摄取较多,生殖腺放射性摄取最少,24 h肝肺放射性摄取偏高;24 h内粪尿排出给药量的83.26%,其中经过尿液排出54.86%,经过粪便排出28.41%。

Uptake,Distribution and Excretion of 63Ni-NiCl2 in Rat

The uptake, distribution and excretion of ⁶³NiNiCl₂ in rat were studied by liquid scintillation counting method. It was observed that the concentration time curves in blood fitted the two dicompart ment model of pharmacokinetics, K_a=6.18 h, T_1/2(α)=0.79 h, T_1/2(β)=40.68 h, CL=0.42 mL·kg^-1·h^-1, T_peak=0.53 h,C_max=14.99 GBq/L, V_d=0.016 L/kg. ⁶³NiNiCl₂ was existed in all of 12 tissues tested; at 0.25 h, radioactivity in intestine were the highest, and that in stomach and fattiness were higher; at 3 h, liver, stomach and intestine were higher; the germen was the least; The liver and lung was the higher at 24 h. In 24 h 83.26% of radioactivity of oral administration was eliminated by urine and feces, 54.86% by urine, 28.41% by feces.