Preparation of High Specific Activity Strontium-89 Solution in High Flux Engineering Test Reactor |
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Authors: | LUO Ning ZENG Junjie CHEN Yunming SUN Zhizhong ZHANG Jinsong LIANG Banghong HU Yin LI Bin ZHONG Jun WANG Xiaobing |
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Affiliation: | 1.Nuclear Power Institute of China, Chengdu 610005, China;2.Sichuan Engineering Research Center for Raidoactive Isotope, Chengdu 610005, China |
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Abstract: | 89SrCl2 is an important radioactive drug for the bone metastasis. It is included in the new pharmacopoeia in 2015 and has a promising future in the market. Depending on the high flux engineering test reactor(HFETR), the process of preparation of high specific activity89SrCl2 solution by nuclear reaction 88Sr(n, γ)89Sr was studied. High purity enriched88SrCO3 was used as target material and irradiated for 56 days under the condition of thermal neutron fluence rate about 2×1014 n•cm-2•s-1. After dissolution and filtration, the colorless89SrCl2 solution was obtained. The specific activity of89SrCl2 solution was 7.77×109-1.08×1010 Bq•g-1, the activity concentration was 3.59×108-1.21×109 Bq•mL-1, the gamma impurity content was 0.11%-0.14%, the Al impurity content was much lower than 2 μg•mL-1(activity concentration 7.4×107 Bq• mL-1).89SrCl2 solution had been tested to meet the requirements of the industry and could be used as raw material for the production of injection. The development of single 7.4×1010 Bq level preparation device of high purity and high specific activity of 89Sr had been finished. This research is important for localization of isotope products. |
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Keywords: | Strontium-89 chloride solution preparation in reactor medical isotopes the high flux engineering test reactor |
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