| D_(12)-孔雀石绿的合成 |
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| 引用本文： | 杨超,杨维成,李美华,罗勇.D_(12)-孔雀石绿的合成[J].同位素,2014,27(2):77-81. |
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| 作者姓名： | 杨超 杨维成 李美华 罗勇 |
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| 作者单位： | 上海化工研究院 上海200062 |
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| 基金项目： | 科技部专制院所专项（2012EG116257）;质检公益性行业科研专项经费资助项目（201310140） |
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| 摘 要： | 以CD_3OD为起始原料,经甲基化、缩合、氧化等步骤合成稳定同位素标记D_(12)-孔雀石绿。以消耗CD_3OD计算,稳定同位素标记D_(12)-孔雀石绿的总收率为50.1%。产品结构经高效液相色谱(HPLC)、质谱(MS)及核磁共振波谱(NMR)等仪器表征确定,D_(12)-孔雀石绿色谱纯度高于99.0%,氘同位素丰度大于99.0%,结果表明,D_(12)-孔雀石绿可作为食品安全领域检测用同位素内标试剂。
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| 关 键 词： | 同位素标记 孔雀石绿 合成 表征 |
Syntheses of Stable Isotope Labeled D12-Malachite Green |
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| YANG Chao,YANG Wei-cheng,LI Mei-hua,LUO Yong.Syntheses of Stable Isotope Labeled D12-Malachite Green[J].Isotopes,2014,27(2):77-81. |
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| Authors: | YANG Chao YANG Wei-cheng LI Mei-hua LUO Yong |
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| Affiliation: | Shanghai Research Institute of Chemical Industry, Shanghai 200062, China |
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| Abstract: | The efficient synthesis of stable isotope labeled D12-Malachite Green with CD3OD as the precursor by methylation, condensation and oxidation was presented. The yields of D12-Malachite Green was 50.1% based on CD3 OD consumed. The product was ideatified by HPLC, MS, and NMR to be the target compound. Its chemical purity and isotopic enrichment were higher than 99.0 atom% D. The result showed that the D12-Malachite Green could be used as internal standard in the field of food safety. |
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| Keywords: | isotope labeled Malachite Green synthesis characterization |
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