| 3-硝基-7-氮杂吲哚类化合物的单电子还原电位的测定 |
| |
| 引用本文： | 金一尊,J.Handman.3-硝基-7-氮杂吲哚类化合物的单电子还原电位的测定[J].辐射研究与辐射工艺学报,1986(4). |
| |
| 作者姓名： | 金一尊 J.Handman |
| |
| 作者单位： | 上海医科大学放射医学研究所，MRC，Radiobiology Unit，Harwell，Oidcot，Dxon oxll ORD，U. K. |
| |
| 摘 要： | 单电子还原电位是测定化合物亲电性的一项数值,通过脉冲辐解方法,在pH=7的缓冲溶液中进行测定(用E_7~1表示)。化合物的单电子还原电位负值的绝对值越小,其亲电性也越大,在绝大部份情况下,化合物的辐射致敏作用与其电子亲和性之间有一定的关系,因此可利用E_7~1值作为初步评价亲电性化合物的辐射致敏作用的指标之一。本文报道某些新的乏氧细胞辐射致敏剂——3—硝基—7—氮杂吲哚类化合物的单电子还原电位值
|
| 关 键 词： | 单电子还原电位 脉冲辐解 电子亲和性 辐射致敏作用 3-硝基-7-氮杂吲哚 |
DETERMINATION OF ONE-ELECTRON REDUCTION POTENTIAL OF 3-NITRO-7-AZAINDOLE COMPOUNDS |
| |
| Jin Yizun,J. Handman Shanghai Medical University.DETERMINATION OF ONE-ELECTRON REDUCTION POTENTIAL OF 3-NITRO-7-AZAINDOLE COMPOUNDS[J].Journal of Radiation Research and Radiation Processing,1986(4). |
| |
| Authors: | Jin Yizun J Handman Shanghai Medical University |
| |
| Affiliation: | Jin Yizun,J. Handman Shanghai Medical University,Shanghai Institute of Radiation Medicine MRC,Radiobiology Unit,Harwell,Oidcot,Oxon OX11 ORD U. K. |
| |
| Abstract: | One-electron reduction potential (E_7~1 ) is a measure of the electronaffinity of the compound by pulse radiolysis at PH 7. The less negative the E_7~1value, the greater is the electron affinity of the compound. Many studies supportedthat the electron affinity is related qualitativety to radiosensitization effectiveness.This paper describes the E_7~1 of some 3-nitro-7-azaindole derivatives. |
| |
| Keywords: | One-electron reduction potential Pulse radiolysis Electron affinity Radiosensitization effectiveness 3-nitro-7-azaindole |
| 本文献已被 CNKI 等数据库收录！ |
