放射工作人员外周血淋巴细胞染色体畸变分析

为了解不同职业照射类型、年龄、工龄放射工作人员外周血淋巴细胞染色体的畸变情况,采集四川省1612名放射工作人员(放射组)和248名健康人员(对照组)外周血,用微量全血培养法培养淋巴细胞,MetaSystems系统分析记录染色体畸变,统计分析染色体畸变率。结果表明,放射工作人员染色体总畸变率显著高于对照组;放射工作人员中,核燃料循环组、工业应用组染色体畸变率明显高于医学应用组,40岁以上人员染色体畸变率高于40岁以下,工龄20年以上人员染色体畸变率高于20年以下。结果提示,放射工作人员较健康人群外周血淋巴细胞染色体畸变明显增加,应进一步提高核燃料循环和工业应用人员的职业防护意识,加强个人辐射防护。

Analysis of Chromosome Aberrations in Peripheral Blood Lymphocytes of Radiation Workers

In order to understand the aberrations of peripheral blood lymphocytes in radiation workers of different occupational exposure types, ages and lengths of service, 1612 radiation workers (radiation group) and 248 non-radiation workers (control group) in Sichuan Province were selected. Peripheral blood lymphocytes were cultured by micro-blood culture method. MetaSystems chromosome analysis system was used to record cell chromosome aberrations. And statistical analysis of chromosome aberration rates was then performed. It indicates that the total chromosome aberration rate of radiation workers was significantly higher than that of the control group. Among the radiation workers, subgroups of nuclear fuel cycle and the industrial application have significantly highernuclear aberration rates than that of the medical application subgroup. The chromosome aberration rate of workers over 40 years old was higher than that of those under 40 years old. As for the length of service, a similar trend was observed, with a boundary of 20 years.This suggest that the chromosomal aberrations of peripheral blood lymphocytes of radiation workers are significantly increased compared with healthy public members. It is necessary to further improve the occupational protection awareness of nuclear fuel cycle and industrial application personnel, and strengthen individual radiation protection.