| 过氧化氢氧化糠胺制备3-羟基吡啶 |
| |
| 引用本文： | 张珍明,李树安,葛洪玉.过氧化氢氧化糠胺制备3-羟基吡啶[J].精细石油化工,2007,24(2):18-20. |
| |
| 作者姓名： | 张珍明 李树安 葛洪玉 |
| |
| 作者单位： | 淮海工学院化学工程系,江苏,连云港,222005 |
| |
| 基金项目： | 江苏省高校高新技术产业发展项目 |
| |
| 摘 要： | 以糠胺为原料、H2O2为氧化剂制备3-羟基吡啶。考察了盐酸浓度、反应温度和反应时间对3-羟基吡啶收率的影响。最佳反应条件为:n(糠胺),n(盐酸):n(过氧化氢)=1．0:5．0:1．1,在0-5℃4 h内将过氧化氢滴加入糠胺和盐酸的混合物中,加热回流反应0．5 h,得目标产物,收率76％,质量分数99．3%。
|
| 关 键 词： | 3-羟基吡啶 糠胺 过氧化氢 制备 |
| 收稿时间： | 2006-08-17 |
| 修稿时间： | 2007-02-12 |
PREPARATION OF 3-HYDROXYPYRIDINE FROM 2-AMINOMETHYLFURAN WITH HYDROGEN DIOXIDE AS OXIDANT |
| |
| Zhang Zhenming,Li Shu'an,Ge Hongyu.PREPARATION OF 3-HYDROXYPYRIDINE FROM 2-AMINOMETHYLFURAN WITH HYDROGEN DIOXIDE AS OXIDANT[J].Speciality Petrochemicals,2007,24(2):18-20. |
| |
| Authors: | Zhang Zhenming Li Shu'an Ge Hongyu |
| |
| Affiliation: | Departmant of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, Jiangsu, China |
| |
| Abstract: | 3-hydroxypyridine was prepared by reacting furfurylamine with H2O2 in the presence of HC1, followed by hydrolysis. The optimal conditions were found as fellows: molar ratio of furfurylamine : HCl: H2O2 = 1 : 5 : 1. 1, and H2O2 added dropwisely at 0 - 5℃, and then refluxed at 100 -105℃for 0. 5 h. After working up, 3-hydroxypyridine was obtained in 76% yield and 99. 3% purity. The effects of reaction temperature, time and the concentration of hydrochloric acid on the yield of 3-hydroxypyridine were investigated. |
| |
| Keywords: | 3-hydroxypyridine furfurylamine hydrogen dioxide preparation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
