| 木瓜提取物预防非甾体抗炎药诱导的小鼠肠黏膜损伤 |
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| 引用本文： | 郭冲,黄可可,曾俊豪,康佳敏,邓昊,魏承亮,赵宗尧,刘朝奇.木瓜提取物预防非甾体抗炎药诱导的小鼠肠黏膜损伤[J].现代食品科技,2019,35(11):45-51. |
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| 作者姓名： | 郭冲 黄可可 曾俊豪 康佳敏 邓昊 魏承亮 赵宗尧 刘朝奇 |
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| 作者单位： | 三峡大学医学院,湖北宜昌,443002;三峡大学肿瘤微环境与免疫治疗湖北省重点实验室,湖北宜昌,443002 |
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| 基金项目： | 国家自然科学基金项目（81473461） |
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| 摘 要： | 为了研究木瓜提取物对非甾体抗炎药(NSAID)引起的小鼠小肠黏膜损伤的预防作用,应用灌胃方式连续6d给与木瓜提取物,在第5 d给与双氯芬酸钠5 mg/mL连续两天灌胃,建立NSAID诱导小肠黏膜损伤模型。检测小肠黏膜通透性及观察小肠黏膜病变情况,检测葡萄糖转运蛋白(GRP-78)、CHOP、肿瘤坏死因子α(TNF-α)、Toll受体4(TLR4)及NLRP的表达水平。FITC-DT测定结果显示正常组相对荧光值(Relative fluorescence value,RFU)为682.7±105.4、模型组2008.3±496.1、木瓜低剂量组为1097.8±501.1、木瓜高剂量组为737.5±275.5;与正常组相比,模型组小鼠小肠黏膜明显损伤及通透性增加;与模型组相比,不同剂量木瓜提取物处理小鼠后能明显减轻小肠黏膜损伤,其机制与木瓜提取物调节肠道组织的内质网应激(GRP78和CHOP)、降低肠道炎症反应(TLR4和TNF-α)有关。提示木瓜提取物能通过调节TLR4-内质网应激预防NSAID对小鼠小肠黏膜的损伤。
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| 关 键 词： | 非甾体抗炎药(NSAID) 小肠黏膜损伤 木瓜提取物 TLR信号通路 内质网应激 |
| 收稿时间： | 2018/11/22 0:00:00 |
Extract of Chaenomeles speciosa (Sweet) Nakai Prevents Intestinal Mucosal Injury Induced by Non-steroidal Anti-inflammatory Drugs (NSAIDs) in Mice |
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| GUO Chong,HUANG Ke-ke,ZENG Jun-hao,KANG Jia-min,DEN Hao,WEI Cheng-liang,ZHAO Zong-yao and LIU Chao-qi.Extract of Chaenomeles speciosa (Sweet) Nakai Prevents Intestinal Mucosal Injury Induced by Non-steroidal Anti-inflammatory Drugs (NSAIDs) in Mice[J].Modern Food Science & Technology,2019,35(11):45-51. |
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| Authors: | GUO Chong HUANG Ke-ke ZENG Jun-hao KANG Jia-min DEN Hao WEI Cheng-liang ZHAO Zong-yao and LIU Chao-qi |
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| Affiliation: | (1.Medical College of China Three Gorges University, Yichang 443002, China),(1.Medical College of China Three Gorges University, Yichang 443002, China),(1.Medical College of China Three Gorges University, Yichang 443002, China),(1.Medical College of China Three Gorges University, Yichang 443002, China),(1.Medical College of China Three Gorges University, Yichang 443002, China),(2.Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China),(1.Medical College of China Three Gorges University, Yichang 443002, China) and (2.Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China) |
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| Abstract: | |
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| Keywords: | NSAID small intestine injury extract of Chaenomeles speciose (Sweet) Nakai TLR signaling pathways endoplasmic stress |
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