板蓝根颗粒质量控制方法的研究

用傅里叶变换红外光谱(FT-IR)结合核磁共振氢谱(IH-NMR)研究了传统中成药板蓝根颗粒的质量控制方法.对其所含主要成分进行了测试与研究,定量分析了其蔗糖的含量,并对不同厂家板蓝根颗粒的甲醇和无水乙醇提取物红外谱图进行了光谱特征的分析.结果表明:醇提可以有效减少板蓝根颗粒中蔗糖等辅料的干扰,使原料的红外谱图特征明显;通过比较不同厂家板蓝根颗粒醇提物红外谱图与板蓝根水提物红外谱图的相似度,可以客观反映板蓝根颗粒的质量;不同厂家的板蓝根颗粒蔗糖含量差异是明显的.因此红外光谱技术结合溶剂提取分析板蓝根颗粒的光谱特征,能够更有效与直硬.反应出不同生产厂家产品质量的差别.

Studies on Quality Control of Banlangen Granules

Fourier transform infrared spectrometry(FT-IR) and nuclear magnetic resonance hydrogen spectrum (1H-NMR) were used for quality control of a chinese traditional patent medicine, Banlangen granules. The main components and sucrose content of Banlangen granules were studied by FTIR spectroscopy. Results showed that alcohol extraction of Banlangen granules can effectively reduce the interference from sucrose on IR characters of Banlangen granules, which was more suitable for the further characterization of Banlangen granules than H2O extraction. Obvious differences in the sucrose content were found in Banlangen granules from different manufactures. This research provided a direct and effective technique for examining the quality of Banlangen granules.