复合苦荞粉通便作用的研究

通过对小鼠做通便药效试验,研究复合苦荞粉的通便作用。以小鼠为试验对象,随机分为5组,即空白对照组、模型对照组和复合苦荞粉低、中、高3个剂量组。采用复方地芬诺酯灌胃建立小鼠便秘模型,通过测定小肠推进率、首次排黑便时间、排黑便粒数以及排黑便质量,判断复合苦荞粉对小鼠肠道蠕动和排便功能的影响。在连续灌胃14 d后,高剂量组小鼠的墨汁推进显著高于模型对照组(p0.05);高剂量组的小鼠排黑便粒数高于模型对照组,呈极显著差异(p0.01),低、中剂量组的排黑便粒显著高于模型对照组(p0.05);各剂量组的排黑便质量均极显著高于模型对照组(p0.01);而首次排黑便时间各剂量组与模型组之间无显著差异。复合苦荞粉能有效增强肠道蠕动并促进排便,改善便秘。

Effect of the Compound Tartary Buckwheat Flour on the Defecation in Mice

Compound buckwheat powder can effectively improve intestinal peristalsis and promote defecation, improve constipation. Effects of the compound tartary buckwheat flour on the defecation were investigated by the laxative efficacy test in mice. Kunming mice were randomly divided into 5 groups, including blank control group, constipation model group, and compound tartary buckwheat flour in the low, middle and high dose groups. The mouse constipation model was established by intragastric administration of diphenoxylate. The effect of compound tartary buckwheat flour on the defecation function was evaluated by measuring the intestinal propulsion rate, first black feces time, the number of black feces in 6 hours and feces weight. After the mice were subjected to continuous intragastric infusion for 14 days, ink-pushing rate in high dose group was significantly higher than that in the constipation model group (p<0.05); the number of black feces in high dose groups was higher than that in the constipation model group (p<0.01), and the number of black feces in low and middle dose group revealed a significant increase when compared with that in the constipation model group (p<0.05); compared with the model group, the feces weight in each compound tartary buckwheat flour treatment groups were higher (p<0.01); however, there were no significant differences on the first defecation time between the compound tartary buckwheat flour treatment groups and the constipation model group. Compound tartary buckwheat flour could effectively improve defecation and intestinal peristalsis.