GC/MS法同时测定电子烟烟气释放物中的5种醇类化合物

为了准确测定电子烟烟气释放物中醇类化合物的量,以1,4-丁二醇为内标建立了同时检测电子烟烟气释放物中1,2-丙二醇、1,3-丁二醇、丙三醇、二甘醇和三甘醇的气相色谱/质谱(GC/MS)方法,采用该法测定了16种电子烟样品。结果表明:①该法的检出限和定量限范围在0.08~0.32μg/口和0.27~1.07μg/口之间;回收率在90.0%~99.5%之间,相对标准偏差(RSD)为1.20%~4.93%。②所测样品中均检出1,2-丙二醇、丙三醇,均未检出二甘醇和三甘醇;4个样品中检测出1,3-丁二醇。该法灵敏度高、定性准确,适合电子烟样品烟气释放物中1,2-丙二醇、1,3-丁二醇、丙三醇、二甘醇和三甘醇的定性定量分析。 

Simultaneous Determination of Five Alcohols in E-cigarette Emissions by Gas Chromatography-Mass Spectrometry

In order to accurately determine the contents of alcohols in e-cigarette emissions,a gas chromatography-mass spectrometry(GC/MS) method was developed for simultaneously determining 1,2-propylene glycol,1,3-butanediol,glycerol,diethylene glycol and triethylene glycol,wherein 1,4-butanediol was used as an internal standard.Sixteen samples of e-cigarette were tested by the developed method.The results showed that:1) The limit of detection and limit of quantitation were 0.08-0.32 and 0.27-1.07 μg/puff,respectively;the recoveries were 90.0%-99.5% with the relative standard deviations(RSD) ranged from 1.20% to 4.93%.2)1,2-Propylene glycol and glycerin were detectable,while diethylene glycol and triethylene glycol were undetectable in all samples;and 1,3-butanediol was detectable in four samples.3) This method was suitable for the qualitative and quantitative determination of 1,2-propylene glycol,1,3-butanediol,glycerol,diethylene glycol,triethylene glycol in e-cigarette emissions.