绿茶提取物EGCG对老年痴呆鼠和肥胖鼠的改善作用研究

以老年痴呆症和肥胖症模型小鼠为实验对象,每天用50 mg/kg的绿茶提取物(-)表没食子儿茶素没食子酸酯(EGCG)喂食30 d,分别从实验鼠的外形、生化指标和组织切片等指标进行分析,探讨EGCG对老年痴呆症和肥胖的改善作用。结果表明,EGCG能改善老年痴呆症小鼠大脑认知水平,作用机制可能与脑组织胆碱乙酰转移酶(ChAT)和乙酰胆碱酯酶(AchE)酶活、丙二醛(MDA)含量和β-淀粉样蛋白-42(Aβ42)沉积有关。EGCG具有抑制肥胖功效,其作用机制可能与体内血清脂肪酶和淀粉酶活力有关,影响脂肪和能量代谢。同时,EGCG还具有一定的修复肥胖引起的肝损伤的作用。这一研究成果为绿茶功能食品的开发奠定了理论基础。

Effect of green tea extract EGCG on the improvement of Alzheimer’s and obesity mice

The present work reports the positive effect of green tea extract EGCG on the improvement of Alzheimer’s and obesity mice with the administration of 50 mg EGCG/kg mice every day for 30 days,and the mechanism is elucidated from three aspects of mice body,biochemical indexes and tissue immunology.The results showed that the EGCG can improve the cognitive function of Alzheimer’s mice,its function mechanism is probably attributed to enzyme activities of choline acetyltransferase(AchE)and acetylcholine esterase(ChAT),as well as the content of malondialdehyde(MDA)in serum and the accumulate ofβ-amyloid protein 42(Aβ42)in the hippocampus.Furthermore,EGCG has a positive effect on the inhibition against obesity desease,it is related to the enzyme activities of lipase and amlyase in serum of obesity mice,which will affect triglycerol metabolism and energy intake.It is worthily noticed that EGCG can protect obesity-induced liver tissue damage.The findings in this work will provide future directions for development of green tea functional foods.