| 固相萃取-超高效液相色谱-串联质谱法测定畜产品中残留的22种磺胺类药物 |
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| 引用本文： | 高洁,陈达炜,丁宇琦,李长坤,赵云峰.固相萃取-超高效液相色谱-串联质谱法测定畜产品中残留的22种磺胺类药物[J].中国食品卫生杂志,2018,30(1):28-34. |
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| 作者姓名： | 高洁 陈达炜 丁宇琦 李长坤 赵云峰 |
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| 作者单位： | 国家食品安全风险评估中心卫生部食品安全风险评估重点实验室;浙江省食品药品检验研究院;岛津企业管理(中国)有限公司; |
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| 基金项目： | 国家自然科学基金青年科学基金项目(21607035)；国家高技术研究发展计划(863计划)项目(2012AA101603) |
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| 摘 要： | 目的建立畜产品中22种磺胺类药物残留的超高效液相色谱-串联质谱(UPLC-MS/MS)测定方法。方法样品经乙腈涡旋提取,正己烷除脂后,阳离子交换固相萃取柱净化,再经Waters Acquity UPLC BEH C_18(2.1 mm×100 mm,1.7μm)色谱柱分离,在电喷雾正离子多反应监测模式下进行测定。结果 22种磺胺类药物在一定的浓度范围内线性关系良好,相关系数(r)0.997。在猪肉、猪肝、猪肾3种基质中,22种磺胺类药物的检出限为0.03~0.3μg/kg,定量限为0.1~1μg/kg。在1、2、5μg/kg三个添加水平下,其加标回收率为63.0%~115.6%,相对标准偏差为1.2%~15.9%。结论该方法快速、简便、准确可靠,适用于畜产品中22种磺胺类药物的同时检测。
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| 关 键 词： | 磺胺类药物 畜产品 超高效液相色谱-串联质谱 固相萃取 同时检测 兽药残留 食品污染物 |
| 收稿时间： | 2018/1/16 0:00:00 |
Determination of 22 sulfonamides in livestock products by ultra high performance liquid chromatography-tandem mass spectrometry coupled with solid phase extraction |
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| GAO Jie,CHEN Da-wei,DING Yu-qi,LI Chang-kun and ZHAO Yun-feng.Determination of 22 sulfonamides in livestock products by ultra high performance liquid chromatography-tandem mass spectrometry coupled with solid phase extraction[J].Chinese Journal of Food Hygiene,2018,30(1):28-34. |
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| Authors: | GAO Jie CHEN Da-wei DING Yu-qi LI Chang-kun and ZHAO Yun-feng |
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| Affiliation: | Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety and Risk Assessment,Beijing 100021, China,Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety and Risk Assessment,Beijing 100021, China,Zhejiang Institute for Food and Drug Control, Zhejiang Hangzhou 310052, China,Shimadzu China Co., LTD, Beijing 100020, China and Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety and Risk Assessment,Beijing 100021, China |
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| Abstract: | |
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| Keywords: | Sulfonamides livestock products ultra high performance liquid chromatography-tandem mass spectrometry solid phase extraction simultaneous determination veterinary drug residue food contaminants |
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