冬虫夏草菌丝体镇咳、祛痰及抗菌消炎作用的研究

本文主要目的为研究冬虫夏草菌丝体镇咳、祛痰及体内外抗菌消炎作用。选用二月龄雌性昆明种小鼠，随机分为空白对照、低剂量（0．5g/kg.bw）和高剂量（1．0g/kg.bw）三组，连续灌胃17天和27天后分别进行镇咳、祛痰和体内抗炎实验；同时还研究了冬虫夏草菌丝体的体外抗菌作用。结果表明：与对照组比较，低剂量虫草菌丝体能降低浓氨水致咳小鼠的咳嗽次数44．4％（P＜0．05），延长咳嗽潜伏期108．1％（P＜0．01），并能降低二甲苯致耳廓肿胀厚度40．2％（P＜0．05）；高剂量虫草菌丝体能降低浓氨水致小鼠的咳嗽次数49．4％（P＜0．01），延长咳嗽潜伏88．4％（P＜0．01），提高酚红排泌量75．0％（P＜0．01）并降低二甲苯致耳廓肿胀厚度36．4％（P＜0．05）。体外抗菌实验显示：虫草菌丝体具有抑制金黄色葡萄球菌、肺炎球菌和乙型链球菌的作用。结果提示冬虫草菌丝体具有镇咳、祛痰和抗菌消炎作用。

Study on Functions of Cordyceps Sinensis Mycelium About Cough - Relief, Expectorant Effect,Antisepsis and Anti - Inflammatory Effect

The purpose of this paper was to investigate the effects of Cordyceps sinensis mycelium on expectoration and cough-orelief.Two-month mice were selected and divided into three groups: control group, low-dose group(0.5g/kg.bw) and high-dose group(1.0g/kg.bw). We conducted the experiment after feeding 17 days and 27 days. The results show that, comparing with the control group, the low-dose Cordyceps decrease the cough times 44.4%(P<0.05)and inhibit inflammation swelling at the ear area of mice 40.2%(P<0.05). The high-dose Cordyceps sinensis mycelium could prolong the incubation period of cough 88.4%(P<0.01),decrease the times of cough 49.4%(P<0.05),inhibit inflammation swelling at the ear area of mice 36.4%(P<0.05) and also accelerate phlegm displacement of mice 75.0%(P<0.01). The ex-vivo experiment showed that Cordyceps sinensis mycelium could inhibit the increment of pneumonocccus, beta streptococcus and staphylococcus aureus. Cordyceps sinensis mycelium had obviously functions of expectorant effect, cough-relief, antiseptisis and antfi-inflammatory effect.