虫草灵芝孢子粉复合物对小鼠免疫功能的影响

目的：探讨虫草灵芝孢子粉复合物对小鼠免疫功能的调节作用。方法：实验将虫草灵芝孢子粉分为低、中、高3个剂量组，并设置对照组，分别喂饲小鼠30d，观察小鼠体质量及免疫器官指数变化、迟发型变态反应(DTH)、ConA诱导的淋巴细胞转化能力、血清溶血素生成、碳廓清能力和巨噬细胞吞噬鸡红细胞能力6个项目。结果：与对照组比较，虫草灵芝孢子粉高剂量组显著提高小鼠胸腺指数，低、中剂量组显著提高小鼠迟发型变态反应，高剂量组显著提高小鼠淋巴细胞的增殖能力，提示虫草灵芝孢子粉能增强小鼠特异性免疫应答。低、中剂量组还能显著提高巨噬细胞碳廓清能力和吞噬鸡红细胞能力，提示虫草灵芝孢子粉可增强正常小鼠巨噬细胞吞噬能力，增强小鼠非特异性免疫应答。结论：虫草灵芝孢子粉复合物能增强小鼠特异性免疫作用和非特异性免疫作用，具有增强小鼠免疫功能的作用。

Effects of Cultured Cordyceps militaris-Ganoderma lucidum Spore Complex on Immune Function in Mice

Objective: To study the modulatory effect of cultured Cordyceps militaris-Ganoderma lucidum spore complex on the immune function of mice. Methods: In this study, mice were orally administered with the complex at low, medium and high doses for 30 days. After the last administration, mouse body weight, immune organ indices, delayed-type hypersensitivity (DTH), T lymphocyte proliferation induced by ConA, serum hemolysin formation, carbon clearance capability and the chicken red blood cell phagocytosis ability of mouse macrophages were assayed. Results: Compared with the control group, the high-dose treatment group significantly improved the body weight and thymus index of mice, the low- and medium- dose treatment groups showed a significant increase in delayed-type hypersensitivity, and the high-dose treatment group significantly enhanced the ability of ConA induced lymphocyte proliferation. These findings suggest that cultured Cordyceps militaris-Ganoderma lucidum spore complex can enhance specific immune responses in mice. Moreover, both the low and medium doses could also significantly enhance mouse carbon clearance capability and the chicken red blood cell phagocytosis ability of mouse macrophages, suggesting that the complex can enhance non-specific immune responses in mice. Conclusions: Cultured Cordyceps militaris-Ganoderma lucidum spore complex can enhance specific immune response and non-specific immune responses in mice, thus enhancing the immune system function of mice.