| 大豆异黄酮对AD大鼠海马PS-1表达的影响 |
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| 引用本文： | 方正清,刘长安,汪远金,朱 洁,白 玫.大豆异黄酮对AD大鼠海马PS-1表达的影响[J].食品科学,2011,32(7):312-314. |
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| 作者姓名： | 方正清 刘长安 汪远金 朱 洁 白 玫 |
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| 作者单位： | 安徽中医学院中西医结合研究所 |
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| 基金项目： | 安徽省自然科学基金项目(070413259X) |
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| 摘 要： | 目的：探讨大豆异黄酮(SIF)对AD大鼠海马PS-1表达的影响。方法：采用β-淀粉样蛋白(Aβ)单侧海马注射建立阿尔茨海默病(AD)大鼠模型，给予相应药物后，利用跳台实验观察AD大鼠学习记忆能力的变化，免疫组化检测AD大鼠海马早老素(PS-1)表达。结果：大豆异黄酮可改善AD大鼠的学习记忆能力(P＜0.01)，显著性降低AD大鼠PS-1表达(P＜0.01)。结论：大豆异黄酮显著降低AD大鼠海马组织PS-1表达，从而改善AD大鼠学习记忆能力。
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| 关 键 词： | 大豆异黄酮 阿尔茨海默病 β-淀粉样蛋白 PS-1 |
| 收稿时间： | 2010-04-23 |
Effect of Soybean Isoflavone on Presenilin-1 Expression in Hippocampus of Rats with Alzheimer,s Disease |
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| FANG Zheng-qing,LIU Chang-an,WANG Yuan-jin,ZHU Jie,BAI Mei.Effect of Soybean Isoflavone on Presenilin-1 Expression in Hippocampus of Rats with Alzheimer,s Disease[J].Food Science,2011,32(7):312-314. |
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| Authors: | FANG Zheng-qing LIU Chang-an WANG Yuan-jin ZHU Jie BAI Mei |
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| Affiliation: | Research Institute of Integrated Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine,
Hefei 230038, China |
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| Abstract: | Objective: To explore the effect of soybean isoflavone (SIF) on the expression of presenilin protein-1 (PS-1) in rats with Alzheimer's disease (AD). Methods: AD rat models were established by unilateral hippocampus injection of Aβ. The changes in learning and memory capability of AD rats were measured by step down test, the expression of PS-1 in hippocampus of rats were measured by immunohistochemical method. Results: Soybean isoflavone (SIF) could improve learning and memory capability of AD rats (P ＜ 0.01) by step down test, and significantly decrease the expression of PS-1 (P ＜ 0.01) in hippocampus of AD model group. Conclusion: Soybean isoflavone (SIF) can decrease PS-1 expression and improve learning and memory capability of AD rats. |
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| Keywords: | soybean isoflavone AD β-amyloid peptide presenilin protein-1 |
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