甘薯糖蛋白SPG-1抗肿瘤及免疫调节作用研究

目的:研究甘薯糖蛋白SPG-1对H22荷瘤小鼠的抗肿瘤作用及免疫调节作用。方法:从“广薯98”中提取SPG-1,通过灌胃给药,研究SPG-1对H22荷瘤小鼠的抑瘤率、存活期、肿瘤细胞有丝分裂指数和脾脏指数、胸腺指数、腹腔巨噬细胞活性的影响。结果:SPG-1对H22实体瘤小鼠具有明显的抑瘤作用(p＜0．05),对H22腹水瘤小鼠具有明显的延长存活期作用(p＜0．05),对H22腹水瘤小鼠的肿瘤细胞有丝分裂具有非常明显的抑制作用(p＜0．01);SPG-1能明显增加H22实体瘤小鼠的脾脏指数(p＜0．01)、胸腺指数(p＜0．05),能明显增强H22实体瘤小鼠的腹腔巨噬细胞活性(p＜0．01)。结论:SPG-1对H22荷瘤小鼠具有明显的抗肿瘤作用且能明显增强H22荷瘤小鼠的免疫功能。

Experimental Study of SPG-1 on Antitumor and Immune Activity of Tumor Mice

Object:To study the antitumor and immune activity of SPG-1 on H22 tumor mice.Methods:Sweet potato glycoprotein(SPG-1)was extracted from the cultivar Guangdong 98.The kunming H22 fumor mice were given SPG-1 by intragastrical injection(i.g.)then the inhibiting rate of tumor growth,life prolongation rate,katyokinesis index of tumor cells,spleen index,thymus index and the activity on macrophage of celiac plexus were studied.Results:SPG-1 can significantly inhibit the tumor growth(p＜0.05)on H22 entity-tumor mice,significantly prolong life(p＜0.05)on H22 bearing-tumor mice.SPG-1 can obviously inhibit karyokinesis of tumor cells(p＜0.01)on H22 bearing-tumor mice,and notably enhanced the spleen index(p＜0.01),the thymus index(p＜0.05 )and the activity on macrophage of celiac plexus(p＜0.01)on H22 entity-tumor mice. Conclusion:SPG-1 has anti-tumor and immune function on H22 tumor mice.