| 呕吐毒素的食品污染、吸收代谢及肠道毒性研究进展 |
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| 引用本文： | 郭红艳,杨家庆,刘园,莫妮娜,贾惠婷,陈焱,郑立友.呕吐毒素的食品污染、吸收代谢及肠道毒性研究进展[J].食品科学,2022,43(19):382-390. |
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| 作者姓名： | 郭红艳 杨家庆 刘园 莫妮娜 贾惠婷 陈焱 郑立友 |
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| 作者单位： | （1.安徽工程大学生物与食品工程学院，安徽 芜湖 241000；2.广州市番禺粮食储备有限公司，广东 广州 510000；3.中粮营养健康研究院有限公司，北京 102209） |
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| 基金项目： | 安徽省重点研究与开发计划项目（202104a06020030）；
安徽工程大学引进人才科研启动基金项目（2021YQQ043；2021YQQ010）；
安徽省工业微生物分子育种工程实验室开放基金项目（ELMB-01）；安徽工程大学校级科研项目（Xjky2022095） |
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| 摘 要： | 呕吐毒素又名脱氧雪腐镰刀菌烯醇（deoxynivalenol，DON），是食品中污染最广泛的单端孢霉烯族化合物，且这类化合物是致吐和厌食毒性最强的真菌毒素。DON由镰刀菌产生，对动物和人体的肠道系统、免疫系统、神经系统、肝、肾、脾等器官和组织产生毒性，具有较强的细胞毒性，其中肠道为其毒性作用的第一道屏障。本文综述DON的食品污染特性、吸收代谢及不同研究模型的肠道毒性，并针对其易转化的特点，总结DON衍生物的肠道毒性，为今后DON及其衍生物的毒理学研究提供参考。
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| 关 键 词： | 脱氧雪腐镰刀菌烯醇 污染 吸收代谢 肠道毒性 衍生物 |
Progress in Research on Food Pollution by and Absorption,Metabolism and Intestinal Toxicity of Vomitoxin |
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| GUO Hongyan,YANG Jiaqing,LIU Yuan,MO Nina,JIA Huiting,CHEN Yan,ZHENG Liyou.Progress in Research on Food Pollution by and Absorption,Metabolism and Intestinal Toxicity of Vomitoxin[J].Food Science,2022,43(19):382-390. |
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| Authors: | GUO Hongyan YANG Jiaqing LIU Yuan MO Nina JIA Huiting CHEN Yan ZHENG Liyou |
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| Affiliation: | (1. College of Biological and Food Engineering, Anhui Polytechnic University, Wuhu 241000, China; 2. Guangzhou Panyu Grain Reserve Corporation, Guangzhou 510000, China; 3. COFCO Nutrition Health Research Institute Co., Ltd., Beijing 102209, China) |
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| Abstract: | Vomitoxin, also known as deoxynivalenol (DON), is the most commonly found trichothecene contaminant in foods and it is the most toxic mycotoxin that causes vomit and anorexia. DON is produced by Fusarium and toxic to organs and tissues such as the intestinal system, immune system, nervous system, liver, kidney and spleen of animals and humans, and has strong cytotoxicity. The intestine is the first barrier against its toxic effect. In this paper, DON pollution characteristics in foods, DON absorption and metabolism, and its intestinal toxicity in different models are reviewed. In view of the easy transformation of DON, the intestinal toxicity of its derivatives also is also summarized. We believe that this paper will provide a reference for toxicological research of DON and its derivatives in the future. |
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| Keywords: | deoxynivalenol pollution absorption and metabolism intestinal toxicity derivative |
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