鞣花酸和尿石素类代谢产物的生物活性及其对肠道健康的作用研究进展

鞣花酸（ellagicacid，EA）作为一种天然抗氧化剂，是一种广泛存在于众多蔬菜、水果及坚果中的多酚类化合物，可经过肠道微生物的代谢生成尿石素类物质。但EA在肠道中的利用度较低；而其代谢产物尿石素类较易被肠道吸收，故被认为是发挥EA抗氧化作用的物质基础。动物模型及临床试验研究表明，EA及其代谢产物尿石素可有效改善肠道微生物菌群、促进肠道健康、预防或抑制肠道疾病的发生发展。EA及尿石素的营养生理作用主要包括抗氧化、抗炎及微生物菌群调控等作用。本文综述了EA及尿石素的结构、代谢途径、生物活性及其在肠道疾病研究中的应用。

A Review of the Bioactivity and Gut Health Benefits of Ellagic Acid and Its Metabolites,Urolithins

Ellagic acid (EA), a natural antioxidant, is a polyphenolic compound found in fruits, nuts, and vegetables. EA can be metabolized by gut bacteria to urolithins. EA has very poor intestinal bioavailability, while urolithins can be more easily absorbed than EA and hence can be considered as the material basis for the antioxidant activity of EA. Various animal and clinical studies indicate that EA and urolithins can improve the intestinal microbial flora, promote intestinal health, and prevent the occurrence and development of intestinal diseases. The bioactivities of EA and urolithins mainly include antioxidation, anti-inflammation, and regulating the intestinal flora. The present paper reviews the chemical structures, metabolic pathways and bioactivities of EA and urolithins and their applications in research on intestinal diseases.