| 菊粉对反式脂肪酸致小鼠胰岛素抵抗的影响 |
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| 引用本文： | 李晓月,张晶晶,张红建,周聪,肖安红.菊粉对反式脂肪酸致小鼠胰岛素抵抗的影响[J].食品科学,2015,36(1):201-204. |
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| 作者姓名： | 李晓月 张晶晶 张红建 周聪 肖安红 |
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| 作者单位： | 1.武汉轻工大学食品科学与工程学院，湖北 武汉 430023；2.湖北省农产品加工与转化重点实验室，湖北 武汉 430023 |
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| 基金项目： | 国家高技术研究发展计划(863计划)项目(2010AA023003-01);武汉市科技计划项目(201220837298-5);武汉工业学院研究生创新基金项目(2012cx016) |
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| 摘 要： | 目的:研究菊粉对反式脂肪酸所致小鼠胰岛素抵抗的影响。方法:采用反式脂肪酸饲料诱导建立小鼠高脂血症模型,分别给予低、中、高3种剂量的菊粉,测定小鼠胰岛素抵抗相关指标。结果:反式脂肪酸的摄入导致小鼠血糖、血清胰岛素水平和胰岛素抵抗指数极显著增加(P0.01),胰岛素敏感指数、胰岛β细胞功能指数和总超氧化物歧化酶活性极显著降低(P0.01)。菊粉干预能够降低小鼠血糖水平和胰岛素抵抗指数,提高胰岛素敏感指数和增强胰岛β细胞功能,且菊粉高剂量干预组与反式脂肪酸组相比,差异均极显著(P0.01),效果最好。结论:反式脂肪酸能够导致小鼠胰岛素抵抗,菊粉干预能够改善小鼠的胰岛素抵抗状况,且高剂量组效果最好。
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| 关 键 词： | 反式脂肪酸 菊粉 小鼠 胰岛素抵抗 高脂血症 |
Effect of Inulin on Insulin Resistance Prevention in Trans Fatty Acids-Fed Mice |
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| LI Xiaoyue;ZHANG Jingjing;ZHANG Hongjian;ZHOU Cong;XIAO Anhong.Effect of Inulin on Insulin Resistance Prevention in Trans Fatty Acids-Fed Mice[J].Food Science,2015,36(1):201-204. |
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| Authors: | LI Xiaoyue;ZHANG Jingjing;ZHANG Hongjian;ZHOU Cong;XIAO Anhong |
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| Affiliation: | 1. College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China;
2. Hubei Key Laboratory for Agro-processing and Transformation, Wuhan 430023, China |
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| Abstract: | Objective: To evaluate the effect of inulin on insulin resistance in trans fatty acids-fed mice. Methods: Inulin was
given at low, medium and high doses. Results: The intake of trans fatty acids elevated fasting blood glucose, fasting serum
insulin, insulin resistance index significantly (P < 0.01), and reduced insulin sensitivity index, islet β-cell function and T-SOD
significantly (P < 0.01). Inulin reduced fasting blood glucose and insulin resistance index, and increased insulin sensitivity
index and islet β-cell function, especially at the high dose, showing significant differences (P < 0.01) when compared with
the trans fatty acid group. Conclusion: Trans fatty acids can lead to insulin resistance in mice, and the intervention of inulin
can improve the symptoms, in particular at the high dose. |
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| Keywords: | trans fatty acids inulin mice insulin resistance hyperlipidemia |
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