响应面试验优化超声波辅助合成地奥司明工艺

以橙皮苷为原料，采用超声波技术，探究地奥司明新型合成路线。在单因素试验基础上，选取超声功率、超声时间、反应时间、反应温度为影响因素，地奥司明得率为响应值，利用Box-Behnken设计原理和响应面试验分析法，研究各因素及其相互作用对得率的影响，模拟得到二次多项式回归方程的预测模型，确定最佳反应条件为：超声功率700 W、超声时间25 min、反应时间5.6 h、反应温度120 ℃。在此条件下，地奥司明合成的得率为21.35%，与理论预测值得率21.78%相比，其相对误差为1.97%，并通过多种波谱方式验证了合成物为目标产物地奥司明。说明通过响应面优化后得到的回归方程具有一定的实践指导意义，同时本实验也为地奥司明的超声波辅助合成提供一定的思路。

Optimization of Ultrasonic-Assisted Synthesis Process of Diosmin by Response Surface Methodology

This study aimed to develop a new ultrasonic-assisted procedure for the synthesis of diosmin from hesperidin.
Four factors including ultrasonic power, irradiation time, reaction time and reaction temperature were optimized using
Box-Behnken design and response surface methodology based on single factor investigations for achieving maximum
yield of diosmin. The optimization was performed by examining the influence of the four independent variables and their
interactions on diosmin yield. A quadratic polynomial regression model equation was set up. By analyzing the response
surface model, the optimum synthesis conditions were determined as follows: ultrasonic power, 700 W; irradiation time, 25
min; reaction time, 5.6 h, and reaction temperature, 120 ℃. Experiments carried out under these conditions gave a diosmin
yield of 21.35%, showing a relative error of 1.97% compared to the predicted value (21.78%). The product was identified as
diosmin by applying various spectroscopic methods. The presented response surface regression equation is of some practical
significance for optimizing the ultrasonic-assisted synthesis of diosmin.