| 食物致敏原表位定位技术的研究进展 |
| |
| 引用本文： | 胡永芯,李欣,程剑锋,马鑫,孟轩夷,陈红兵,武涌.食物致敏原表位定位技术的研究进展[J].食品科学,2021,42(7):292-300. |
| |
| 作者姓名： | 胡永芯 李欣 程剑锋 马鑫 孟轩夷 陈红兵 武涌 |
| |
| 作者单位： | （1.南昌大学 食品科学与技术国家重点实验室，江西 南昌 330047；2.南昌大学食品学院，江西 南昌 330047；3.南昌大学中德联合研究院，江西 南昌 330047） |
| |
| 基金项目： | “十三五”国家重点研发计划重点专项（2018YFC1604205）；国家自然科学基金重点项目（31760431） |
| |
| 摘 要： | 食物致敏原是引起食物过敏的元凶，多为蛋白质。抗原表位是在抗原分子中与抗体反应或被抗原受体识别，并引发机体免疫应答的特殊化学基团。从表位水平认识食物致敏原，能揭示食物过敏的物质基础，为解决食物过敏问题提供精准的靶标。本文基于表位结构和定位方法的不同，介绍了食物致敏原表位定位技术的发展，并进一步展望了致敏原表位信息对于改进食物过敏鉴定技术和低致敏食物加工方法的应用前景。
|
| 关 键 词： | 食物致敏原 表位定位 T细胞表位 B细胞表位 线性表位 构象性表位 |
Advances in Food Allergen Epitope Localization Technologies |
| |
| HU Yongxin,LI Xin,CHENG Jianfeng,MA Xin,MENG Xuanyi,CHEN Hongbing,WU Yong.Advances in Food Allergen Epitope Localization Technologies[J].Food Science,2021,42(7):292-300. |
| |
| Authors: | HU Yongxin LI Xin CHENG Jianfeng MA Xin MENG Xuanyi CHEN Hongbing WU Yong |
| |
| Affiliation: | (1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China; 2. College of Food Science and Technology, Nanchang University, Nanchang 330047, China; 3. Sino German Joint Research Institute, Nanchang University, Nanchang 330047, China) |
| |
| Abstract: | Food allergens are the major causes of food allergies, which are mainly proteins. The antigen epitope is a special chemical group in the antigen molecule, which can react with antibody or be recognized by the antigen receptor, and trigger the body’s immune response. Understanding food allergens at the epitope level can reveal the material basis of food allergic reactions and provide precise targets for solving the problem of food allergy. This paper reviews the development of food allergen epitope localization technologies based on different epitope structures and localization methods, and discusses further prospects for the application prospects of allergen epitope information for improving the existing food allergen identification technologies and hypoallergenic food processing methods. |
| |
| Keywords: | food allergen epitope mapping T cell epitope B cell epitope linear epitope conformational epitope |
|
| 点击此处可从《食品科学》浏览原始摘要信息 |
|
点击此处可从《食品科学》下载全文 |
|
