| 熊果酸对小鼠体细胞的遗传毒性研究 |
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| 引用本文： | 姜玮,张博超,邵薇璇,何晓庆,张存花,卢静.熊果酸对小鼠体细胞的遗传毒性研究[J].食品科学,2008,29(11). |
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| 作者姓名： | 姜玮 张博超 邵薇璇 何晓庆 张存花 卢静 |
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| 作者单位： | 吉林大学军需科技学院食品质量与安全系 |
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| 摘 要： | 目的:探讨熊果酸对小鼠体细胞的遗传毒性,为其应用提供安全性毒理学评价依据。方法:用小鼠骨髓嗜多染红细胞(PCE)微核实验,检测小鼠骨髓嗜多染红细胞微核率;利用小鼠染色体畸变实验,观察不同浓度的熊果酸致小鼠畸形的数目。结果:小鼠骨髓嗜多染红细胞微核实验显示,熊果酸三个剂量组的微核发生率均在正常范围内,与阴性对照组比较无显著性差异(p>0.05),与阳性对照组比较差异显著(p<0.05);小鼠染色体畸变实验可见,熊果酸3个剂量组的小鼠染色体率均在正常范围内,与阴性对照组比较无显著性差异(p>0.05),与阳性对照组比较差异显著(p<0.05)。结论:熊果酸对小鼠体细胞无诱变性。
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| 关 键 词： | 熊果酸 骨髓细胞微核试验 染色体畸变实验 |
Study on Genetic Toxicity of Ursolic Acid to Bone Marrow Cells of Mice |
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| JIANG Wei,ZHANG Bo-chao,SHAO Wei-xuan,HE Xiao-qing,ZHANG Cun-hua,LU Jing.Study on Genetic Toxicity of Ursolic Acid to Bone Marrow Cells of Mice[J].Food Science,2008,29(11). |
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| Authors: | JIANG Wei ZHANG Bo-chao SHAO Wei-xuan HE Xiao-qing ZHANG Cun-hua LU Jing |
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| Abstract: | Objective:To investigate the genetic toxicity of ursolic acid to bone marrow cell for its safety.Methods:By mouse bone marrow polychromatic erythrocyte micronucleus test,the micronucleus rate was measured.Mammalian bone marrow cell chromosome aberration test was persformed to assess the numbers of deformed chromosome.Results:The micronucleus rates and numbers of deformed chromosome of different groups of ursolic acid are all negative(compared with negative control p>0.05,compared with positive control p<0.05).Conclusion:Ursolic acid is nonmutagenic to somatic cell in mice. |
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| Keywords: | ursolic acid bone marrow cell micronucleus test mammalian bone marrow cell chromosome aberration test |
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