同位素示踪氨基葡萄糖硫酸钠的制备及其经皮吸收作用的研究

以放射性同位素标记的氨基葡萄糖盐酸钠为原料制备放射性同位素标记的氨基葡萄糖硫酸钠,同时观察其穿过离体实验动物皮肤的能力。结果表明,经红外线检测证实本研究制备的放射性同位素标记的氨基葡萄糖硫酸钠的结构与氨基葡萄糖硫酸钠标准品完全相同。同位素示踪研究结果显示,实验中制备的放射性同位素标记的氨基葡萄糖硫酸钠可穿过扩散池内的离体实验动物皮肤,进入皮下组织。

Preparation of Glucosamine Sulphate Sodium Marked by Radio Isotope and Its Percutaneous Absorption

This study prepared glucosamine sulfate with glucosamine hydrochloride marked by radio isotope and observed the osmosis ability of glucosamine sulfate passing through skin in vitro of test animal. The infrared ray assay results showed that the structure of glucosamine sulfate marked by radio isotope is same as standard. Isotope tracer technique showed that glucosamine sulfate above can pass through the skin in vitro of test animal in a diffusion cell and osmose into subcutaneous tissue.