| 苦瓜多糖降血糖活性的高通量筛选研究 |
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| 引用本文： | 何新益,刘仲华.苦瓜多糖降血糖活性的高通量筛选研究[J].食品科学,2007,28(2):313-316. |
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| 作者姓名： | 何新益 刘仲华 |
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| 作者单位： | 长沙理工大学生物与食品学院； 湖南农业大学教育部茶学重点实验室 湖南长沙410076 .湖南农业大学教育部茶学重点实验室； 湖南长沙410128； |
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| 摘 要： | PPAR与2型糖尿病存在密切关系,该受体已成为抗2型糖尿病的主要靶点。本文以PPAR三种亚型PPARα、PPARγ和PPARβ/δ为靶点的高通量筛选模型,对苦瓜多糖进行活性筛选。筛选结果表明苦瓜多糖对PPARδ和PPARγ具有较强的激活效果,其激活倍数分别达1.995、1.689。苦瓜多糖是一种潜在的降糖、降脂的活性成分。
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| 关 键 词： | PPAR HTS 苦瓜 2型糖尿病 |
| 文章编号： | 1002-6630（2007）02-0313-04 |
| 修稿时间： | 2006-02-28 |
Study on HTS Anti-diabetic Antagonists from Momordica charantia L. |
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| HE Xin-yi,LIU Zhong-hua.Study on HTS Anti-diabetic Antagonists from Momordica charantia L.[J].Food Science,2007,28(2):313-316. |
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| Authors: | HE Xin-yi LIU Zhong-hua |
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| Affiliation: | 1.College of Biochemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410076, China; 2.Key Laboratory of Tea Science, Ministry of Education, Hunan Agricultural University, Changsha 410128, China |
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| Abstract: | It is found that type 2 diabetes millitus is closely related to PPAR which is now employed as main target anti-diabetes to treatment of type 2 diabetes millitus. Momordica charantia L. is a traditional Chinese medical herb. Recent research showed that there were some hypoglycemic active components in Momordica charantin L. Screening PPARα,β/δ,γ antagonits from Momordica Charantia extracts by HTS was studied in this paper. Results showed that MCP(Momordica charantia polysaccharides) was an antagonist of PPARγand PPARβ/δand the activiation times are 1.689 and 1.995, respectively. MCP can be a potential anti-diabetica gent. |
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| Keywords: | PPAR HTS |
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