| 黄芪多糖对2型糖尿病胰岛素抵抗大鼠Resistin蛋白表达的影响 |
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| 引用本文： | 刘洪凤,陈宏娟,王桂云,韩智学,张杰.黄芪多糖对2型糖尿病胰岛素抵抗大鼠Resistin蛋白表达的影响[J].中国食物与营养,2012,18(1):69-71. |
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| 作者姓名： | 刘洪凤 陈宏娟 王桂云 韩智学 张杰 |
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| 作者单位： | 1. 牡丹江医学院生物化学教研室,黑龙江牡丹江,157011
2. 牡丹江医学院红旗医院,黑龙江牡丹江,157011 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目（项目编号：11551523） |
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| 摘 要： | 目的：探讨黄芪多糖（Astragalus Polysaccharide,APS）对2型糖尿病大鼠脂肪组织抵抗素（Resistin）蛋白表达的影响。方法：将Wistar大鼠随机分为正常对照组、模型组、APS高、中、低剂量治疗组。用药12周后,采用SDS-PAGE检测Resistin蛋白质表达水平。结果：APS高、中剂量治疗组Resistin蛋白表达低于模型组水平（P〈0.01）。结论：APS可下调2型糖尿病大鼠Resistin蛋白表达,从而实现其降血糖作用。
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| 关 键 词： | 黄芪多糖 2型糖尿病 胰岛素抵抗 抵抗素 |
Effect of Astragalus Polysaccharides on Insulin Resistamce and Protein Expression of Resistin in Type 2 Diabetes Mellitus Rats |
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| LIU Hong-feng,CHEN Hong-juan,WANG Gui-yun,HAN Zhi-xue,ZHANG Jie.Effect of Astragalus Polysaccharides on Insulin Resistamce and Protein Expression of Resistin in Type 2 Diabetes Mellitus Rats[J].Food and Nutrition in China,2012,18(1):69-71. |
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| Authors: | LIU Hong-feng CHEN Hong-juan WANG Gui-yun HAN Zhi-xue ZHANG Jie |
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| Affiliation: | 1(1The Department of Biochemistry and Molecular Biology,Mudanjiang Medical College,Mudanjiang 157011,China;2The Department of Hongqi Hospital,Mudanjiang Medical College,Mudanjiang 157011,China) |
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| Abstract: | 【Objective】 To investigate the effect of Astragalus Polysaccharides（APS） on protein expression of resistin of rats with type 2 diabetes mellitus.【Method】 Wistar rats were randomly divided into the control group,model group and high,middle,low doses of APS groups.The protein expression of resistin was determind by SDS-PAGE at the end of 12 weeks.【Result】 The protein expression of resistin decreased in the middle and high doses of APS groups.【Conclusion】 APS could decrease insulin resistance by decreasing protein expression of resistin in 2-DM rats. |
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| Keywords: | APS 2-DM IR resistin |
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