大蒜提取物对小鼠免疫调节作用的实验研究

目的：研究大蒜提取物（Allium sativum extract，ASE）对正常小鼠免疫功能的影响。方法：将40只清洁级昆明种小鼠随机分为空白对照组0．1mL蒸馏水／（10g·bw）]、大蒜提取物高剂量组900mg／（kg·bw）]、大蒜提取物中剂量组600mgJ（kg·bw）]、大蒜提取物低剂量组300mg／（kg·bw）]，每组10只，各组每天灌胃1次，连续给药14d。观察大蒜提取物对正常小鼠免疫器官重量、巨噬细胞吞噬功能等的影响。结果：大蒜提取物能增强正常小鼠巨噬细胞吞噬功能（P〈Qc15），对免疫器官指数也有增加作用（P〈Q（15）。结论：大蒜提取物能增强正常小鼠的免疫功能。

Effects of Allium sativum Extract on Immunity Function in Mice

Objective] To investigate the effects of AUium sativum extract （ASE） on immunity function in mice. Method] Healthy KM mice were randomly divided into 4 groups including blank group 0. 1 mL distilled water /10 （ g · bw ） ], ASE high dosage group 900 mg/（kg ~ bw）], ASE middle dosage group 600 mg/（kg · bw）] and ASE low dosage group 300 mg/ （kg · bw] . Each group of 10 were intragastrically administered continuously once every day for 14d. Result] ASE could the phagocytic function of macrophages in nor- mal mice （P 〈0. 05 ） and the weight of immune organs had improved. Conclusion] ASE can enhance the immunity function of normal mice.