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Effects of dietary flaxseed oil on cholesterol metabolism of hamsters
Authors:Bor-Show Tzang  Shun-Fa Yang  Shih-Guei Fu  Hui-Chun Yang  Hai-Lun Sun  Yi-Chen Chen
Affiliation:1. Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan;2. Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan;3. Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan;4. Department of Applied Life Science, Cha-Nan University of Pharmacy and Science, Tainan County 700, Taiwan;5. School of Nutrition, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd.,Taichung city 402, Taiwan;6. Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan
Abstract:High-fat/cholesterol diets (HFCD) formulated by addition of butter (BU), coconut oil (CO), or flaxseed oil (FX) enhanced (P < 0.05) serum lipids of hamsters compared to the low-fat/cholesterol diet (Control). However, FX groups showed a hypocholesterolaemic effect compared to CO and BU groups. Lower (P < 0.05) hepatic triacylglycerol and cholesterol contents were measured in FX groups than those of CO and BU groups; whereas, higher (P < 0.05) faecal triacylglycerol and cholesterol contents were observed in FX groups. HMG-CoA reductase mRNA expression was upregulated (P < 0.05) by HFCD, whilst FX groups showed no (P > 0.05) influence on LDL-receptor mRNA expression compared to that of Control groups; however, higher (P < 0.05) than those of CO and BU groups. Meanwhile, there was a tendency towards higher CYP7A1 expression in the CO or FX group than the BU group. Thus, the hypocholesterolaemic effect of FX might result from increases of LDL-receptor mRNA expression, and cholesterol catabolism/output.
Keywords:Flaxseed oil  Serum lipids  Hepatic cholesterol/triacylglycerol contents  Faecal cholesterol/triacylglycerol excretion  HMG-CoA reductase  CYP7A1  LDL receptor
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