Hypocholesterolaemic effects of different chitosan samples in vitro and in vivo |
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Authors: | Jingna Liu Jiali Zhang Wenshui Xia |
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Affiliation: | 1. State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, PR China;2. School of Medicine and Pharmaceutics, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, PR China |
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Abstract: | This study determined the hypocholesterolaemic effects of chitosan preparations with different physicochemical properties. Chitosans with smaller particle size had better cholesterol-binding capacities. Chitosans exhibited potent hypocholesterolaemic effect in rats; those with higher degree of deacetylation and molecular weight seemed to reduce plasma triglyceride, total cholesterol and low-density-lipoprotein cholesterol levels and elevate the high-density-lipoprotein cholesterol level more effectively, although not all differences were significant. We concluded that the hypocholesterolaemic mechanism of chitosan was by adsorption, electrostatic force and entrapment. |
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Keywords: | Chitosan Hypocholesterolaemic Particle size Degree of deacetylation Molecular weight |
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