Lentinus edodes heterogalactan: Antinociceptive and anti-inflammatory effects |
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| Authors: | ER Carbonero AHP Gracher DL Komura R Marcon CS Freitas CH Baggio ARS Santos G Torri PAJ Gorin M Iacomini |
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| Affiliation: | 1. Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CP 19046, CEP 81531-980 Curitiba, PR, Brazil;2. Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis 88049-900, SC, Brazil;3. Departamento de Farmacologia, Universidade Federal do Paraná, CP 19031, CEP 81531-980 Curitiba, PR, Brazil;4. Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis 88040-900, SC, Brazil;5. Istituto di Ricerche Chimiche e Biochimiche “G. Ronzoni”, Via Colombo n. 81, 20133 Milan, Italy |
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| Abstract: | Cold aqueous extraction of basidiocarps (fruiting bodies) of the edible mushroom Lentinus edodes (shiitake) gave rise to a heteropolysaccharide, whose chemical structure, antinociceptive and anti-inflammatory properties were determined. Its chemical structure was based on monosaccharide composition, methylation analysis, and NMR spectroscopy (1H, 13C, HSQC, HSQC-TOCSY, HSQC-NOESY, and coupled HMQC). It was found to be a fucomannogalactan with a main chain of (1 → 6)-linked α-d-galactopyranosyl units, partially substituted at O-2 by single-unit β-d-Manp or α-l-Fucp side chains. The polysaccharide produced a marked and dose-related effect when assessed against acetic acid-induced visceral nociception. Prevention of peritoneal capillary permeability and leukocyte infiltration caused by the acetic acid was similar in potency and effectiveness. |
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| Keywords: | Lentinus edodes Shiitake Basidiocarps Polysaccharide Fucomannogalactan Antinociceptive Anti-inflammatory effects |
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