Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis) |
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| Affiliation: | 1. Department of Food Science and Center for Advanced Food Technology, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901-8520, USA;2. Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854-8520, USA;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China;1. Federal State Budgetary Scientific Institution «GOSMETODCENTR», Lusinovskaya 51, 115093, Moscow, Russia;2. Russian International Academy for Tourism, Oktyabrskaya 10, 141420, micro district Skhodnya, Khimky city area, Moscow region, Russia;3. University of Belgrade, Institute of General and Physical Chemistry, Studentski trg 12/V, 11158, Belgrade, Serbia;4. University of Kragujevac, Faculty of Hotel and Tourism Management in Vrnjačka Banja, Vojvodjanska ulica bb, 36210, Vrnjačka Banja, Serbia;5. University of Novi Sad, Faculty of Agriculture, Trg Dositeja Obradovica 8, 21000, Novi Sad, Serbia;6. University of Novi Sad, Faculty of Technology, Bulevar Cara Lazara 1, 21000, Novi Sad, Serbia;7. University of Novi Sad, Technical Faculty “Mihajlo Pupin” Zrenjanin, Djure Djakovica b.b., 23000, Zrenjanin, Serbia;8. University of Belgrade, Faculty of Chemistry, Studentski trg 12, 11158, Belgrade, Serbia;1. Laboratory of infectious diseases and biological agents (LR99ES27), faculty of pharmacy, Monastir university, avenue Avicenne, 5000 Monastir, Tunisia;2. Buccodental surgery department of Monastir dental clinic, laboratory of oral health and orofacial rehabilitation (LR12ES11), Monastir, Tunisia;3. Laboratory of microbiology, university hospital of Fattouma Bourguiba, Monastir, Tunisia;1. Graduate Program in Dentistry, Federal University of Paraíba (UFPB), João Pessoa, 58051-900, Paraíba, Brazil;2. Graduate Program in Dentistry, Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, 13414-903, SP, Brazil;3. Human Immunology Research and Education Group (GEPIH), Technical School of Health (Escola Técnica de Saúde, Universidade Federal da Paraíba) – UFPB, João Pessoa, 58051-900, PB, Brazil;1. Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;2. Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical sciences, Tehran, Iran |
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| Abstract: | Bay leaf belongs to the family Lauraceae, and it is one of the most popular culinary spices in all Western countries. Bay leaf has been used as herbal medicine and has pharmacological activity which includes anti-bacterial, anti-fungal, anti-diabetes and anti-inflammatory effects. The goal of this study was to identify compounds from Bay leaf (Laurus nobilis), which are responsible for inducing apoptosis using bioassay-directed isolation. The isolation of active compounds was carried out in three steps: multiple extractions, fractionation using column chromatography and purification using semi-preparative HPLC. The structure of separated compounds was determined on the basis of 1H, 13C nuclear magnetic resonance data, atmospheric pressure chemical ionization mass spectrometry data, and electron ionization mass spectrometry. Six compounds were identified; all of them are sesquiterpene lactones. |
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