Kinetic analysis of bile salt passage across a dialysis membrane in the presence of cereal soluble dietary fibre polymers |
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Authors: | Purnima Gunness Bernadine M Flanagan Kinnari Shelat Robert G Gilbert Michael J Gidley |
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Affiliation: | 1. Centre for Nutrition and Food Sciences (CNAFS), Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Australia;2. ARC Centre of Excellence in Plant Cell Walls, The University of Queensland, Australia |
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Abstract: | The kinetics of passage of a model bile salt and complete porcine bile across a dialysis membrane, in the presence and absence of two cereal-derived soluble dietary fibre polysaccharides, were studied as a model for passage across the unstirred water layer that lines the small intestine. A first-order kinetic analysis allowed rate coefficients to be derived which quantified the effectiveness of barley mixed linkage β-glucan and wheat arabinoxylan in retarding the transport of bile. For both, a model bile salt and complete porcine bile, rate coefficients decreased with both concentration and viscosity. A combination of viscosity and molecular interaction effects is suggested to control the effect of the two polysaccharides on the transport of bile. |
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Keywords: | AX arabinoxylan βG (1 3:1 4)-β-d-glucan BS bile salt CMC critical micelle concentration TCDC taurochenodeoxycholate SDF soluble dietary fibre UWL unstirred water layer |
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