基于苦荞的功能醋粉对L-NNA诱导高血压大鼠降血压及抗氧化作用

制备一种基于苦荞的功能醋粉，通过给药N-硝基-L-精氨酸建立高血压大鼠模型，对该醋粉的降血压、抗氧化效果进行评估。结果表明，功能醋粉能够显著降低大鼠的血压（P＜0.05）；对于大鼠体质量、心率、肝质量的非正常增长有显著的缓解作用（P＜0.05）；能够显著地稳定大鼠血清中一氧化氮（NO）、内皮素（ET）-1及肿瘤坏死因子（TNF）-α的含量（P＜0.05）；对于大鼠肝脏的过氧化氢酶（CAT）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-PX）的非正常变化有极显著的缓解作用（P＜0.01），对高血压引起的肝脏总抗氧化能力（TAC）和总超氧化物歧化酶（T-SOD）水平的降低有显著的缓解作用（P＜0.05）。说明功能醋粉能够降低大鼠血压、提升大鼠抗氧化能力，其中功能醋粉高剂量组的改善作用更为显著。

Effect of tartary buckwheat-based functional vinegar powder on lowering blood pressure and antioxidant activity of L-NNA-induced hypertensive rats

The functional vinegar powder based on tartary buckwheat was prepared, and the hypertensive rat model was established by administering N-nitro-L-arginine to evaluate the blood pressure and antioxidant effects of the vinegar powder. The results showed that the blood pressure of rats was significantly decreased by functional vinegar powder (P＜0.05). The abnormal increase for rats weight, heart rate, liver mass was significantly alleviated (P＜0.05). The contents of nitric oxide (NO), endothelin (ET)-1 and tumor necrosis factor (TNF)-α in rat serum were significantly stabilized (P＜0.05). The abnormal change of the catalase (CAT), malondialdehyde (MDA), glutathione peroxidase (GSH-PX) of rat liver was significantly alleviated (P＜0.01), and the reduction of total antioxidant capacity (TAC) and total super oxygen dismutase (T-SOD) level of liver induced by hypertension were significantly alleviated (P＜0.05). It showed that functional vinegar powder could reduce blood pressure and enhance antioxidant capacity of rats, and the effect of high dose group was more significant.