益生菌对免疫细胞的影响及其在自身免疫性疾病中的应用

益生菌是一类摄入适当数量时会对宿主健康产生有益作用的活性微生物的总称,可以通过调节树突细胞(dendritic cell,DC)、单核细胞、调节性T细胞(regulatory cells,Treg)和Th17细胞介导的免疫反应,从而发挥其免疫调节能力。自身免疫性疾病(autoimmune diseases,AID)是机体免疫系统对自身组织细胞发生免疫应答,导致细胞破坏或组织损伤所引起的疾病。针对AID的治疗,目前尚无根治药物,传统的糖皮质激素和免疫抑制剂虽能够抑制病情,提高患者存活率,但长期使用会造成一系列不良后果。而大量研究发现益生菌能够有效缓解自身免疫性疾病。本文就益生菌对多种免疫细胞的影响及在自身免疫性疾病中的研究进展进行了综述。

Effects of Probiotics on Immune Cells and Their Application in Autoimmune Diseases

Probiotics are a group of active microorganisms which have beneficial effects on host health when ingested in an appropriate amount. They play an important role in immune regulation by regulating the immune responses of dendritic cells(DC),monocytes,regulatory cells(Treg)and Th17 cells. Autoimmune diseases(AIDs)are diseases caused by the body's immune system,which cause cell destruction or tissue damage. For the treatment of AID,there is no radical medicine at present. Although traditional glucocorticoid and immunosuppressant can inhibit the rapid development of disease and improve the survival rate of patients,long-term use will cause a series of side effect. A large number of studies have found that probiotics can effectively alleviate autoimmune diseases. This paper summarizes the effects of probiotics on a variety of immune cells and the progress in autoimmune diseases.