6-姜烯酚抗肿瘤机制研究进展

癌症的发病率与死亡率逐年递增，严重威胁人类健康。6-姜烯酚是生姜中一种主要活性成分，因其具有安全、低毒的优势成为国内外学者关注的热点，6-姜烯酚具有抗炎、抗氧化、抗肿瘤等药理作用，尤其是其抗肿瘤活性日趋成为研究焦点。本文对6-姜烯酚的抗肿瘤作用机制进行综述，主要包括抑制细胞增殖、诱导细胞凋亡、阻滞细胞周期、抑制细胞的迁移和侵袭、影响肿瘤细胞自噬等，以期为6-姜烯酚抗肿瘤的进一步研究、开发和应用提供思路。

Research Progress on Antitumor Mechanism of 6-Shogaol

The incidence and mortality of cancer are increasing year by year, which seriously threatens human health. 6-Shogaol, as one of the main active components in ginger, has become the focus of attention in recent years due to its advantages of safety and low toxicity. Moreover, it has anti-inflammatory, antioxidant, anti-tumor and other pharmacological effects. Particularly, its anti-tumor activity has received increasing attention. This paper reviews the anti-tumor mechanism of 6-shogaol, including inhibition of cell proliferation, induction of cell apoptosis, arrest of cell cycle, inhibition of cell migration and invasion, effect of autophagy in tumor cells, etc., in order to provide ideas for further research, development and application of 6-shogaol in anti-tumor.