铁蛋白铁氧化沉淀机理研究进展

铁素的缺乏严重影响着全球近一半人的健康,传统的补铁制剂由于会时人体产生副作用逐渐被禁止使用,因此,寻找安全、高效的补铁制剂势在必行.铁蛋白是广泛存在于生物体中的一种铁贮藏蛋白,它具有去除铁的毒性以及调节铁代谢平衡的双重功能.研究表明,铁蛋白具有良好的补铁活性,所以它可以作为加工原料被开发成补铁型功能食品,为此,对铁蛋白理化性质及其生物学功能的阐明就显得颇为重要.目前,有关铁蛋白的基础研究主要集中于铁蛋白的铁氧化沉淀和还原释放机理的研究,相对于后者而言,铁蛋白铁氧化沉淀机理的研究比较清楚.本文综述了国内外有关铁蛋白铁氧化沉淀机理的研究进展,以期为以后新型补铁功能食品的开发提供理论依据.

Research progress in mechanism of iron oxidative deposition in ferritin

Iron deficiency is a problem that has seriously impacted on nearly half of global human health.The traditional preparation of iron supplementation has been gradually prohibited as a result of side effects on human beings.Therefore, it is imperative to look for a safe and efficient preparation of iron supplementation. Ferritin is a class of iron storage protein presented in all living organisms and serves the dual function of iron detoxification and iron metabolism. Research indicated that ferritin had a good iron activity, and it could be developed into iron functional food as raw materials.For this reason, it is important to clarify the physical and chemical properties of ferritin and its biological function.At present, the basic research focused on the mechanism of iron oxidative deposition and reductive release in ferritin.Compared with the latter,the iron oxidative deposition mechanism is more clearly.In this paper,the research progress about the iron oxidative deposition mechanism were summarize, in order to provide a theoretical basis for the development of new type iron functional food.