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茯苓多糖在人工胃液、肠液中的降解及其在体肠吸收研究
引用本文:曹楠,赵珍,赵雨彤,姜天洋,储京,张越,陈卫东,俞年军.茯苓多糖在人工胃液、肠液中的降解及其在体肠吸收研究[J].食品工业科技,2020,41(21):299-303.
作者姓名:曹楠  赵珍  赵雨彤  姜天洋  储京  张越  陈卫东  俞年军
作者单位:1. 安徽中医药大学药学院, 安徽合肥 230012;2. 安徽省中医药科学院药物制剂研究所, 安徽合肥 230012;3. 安徽省中医药科学院中药资源保护与开发研究所, 安徽合肥 230012
基金项目:安徽省重大专项(18030801131)国家重点研发计划项目(2017YFC1701600,2017YFC1701601,2017YFC1701602,2017YFC1701603,2017YFC1701605)国家级大学生创新创业项目(201910369037)。安徽省中央引导地方科技发展专项资金(201907d07050002)
摘    要:以茯苓多糖为研究对象,通过体外模拟人体胃肠道环境及在体循环肠灌流过程,研究其在大鼠体内的消化吸收情况。首先检测茯苓多糖在人工胃液中的降解,随后检测胃降解液在人工肠液中的降解,最后探究胃肠液降解后的多糖在体肠中的吸收。结果显示:茯苓多糖在人工胃液中0.5 h内被迅速降解完全,生成许多在胃液中稳定存在的片段,且在肠液中几乎不被降解。茯苓多糖主要在体肠被吸收,且初始多糖浓度越大吸收百分率(ρ)越大;吸收过程中,不同初始浓度的多糖溶液,其吸收速率常数(Ka)均呈现先增加后降低的趋势;吸收至120 min时,初始多糖浓度为0.1004、0.5007、1.0004 mg/mL的胃肠降解液的吸收百分率ρ分别达到(23.52%±0.57%)、(49.14%±0.87%)、(57.56%±0.22%)。研究表明:茯苓多糖在大鼠体内主要在胃液中降解、体肠中吸收。

关 键 词:茯苓多糖    肠灌流    降解    吸收
收稿时间:2019-10-12

Study on Degradation and Intestinal Absorption of Poria cocos Polysaccharides in Artificial Gastric Juice and Intestinal Juice
CAO Nan,ZHAO Zhen,ZHAO Yu-tong,JIANG Tian-yang,CHU Jing,ZHANG Yue,CHEN Wei-dong,YU Nian-jun.Study on Degradation and Intestinal Absorption of Poria cocos Polysaccharides in Artificial Gastric Juice and Intestinal Juice[J].Science and Technology of Food Industry,2020,41(21):299-303.
Authors:CAO Nan  ZHAO Zhen  ZHAO Yu-tong  JIANG Tian-yang  CHU Jing  ZHANG Yue  CHEN Wei-dong  YU Nian-jun
Affiliation:1. College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China;2. Institute of Pharmaceutical Preparations, Anhui Academy of Traditional Chinese Medicine, Hefei 230012, China;3. Anhui Academy of Traditional Chinese Medicine Resources Protection and Development Research Institute, Hefei 230012, China
Abstract:Taking Poria cocos polysaccharide as the research object,the digestion and absorption process of Poria cocos polysaccharide in rats was studied by simulating human gastrointestinal environment in vitro and intestinal perfusion in vivo. In this experiment,the degradation of Poria cocos polysaccharide in artificial gastric juice was detected,then the degradation of gastric degradation fluid in artificial intestinal juice was detected,and finally the absorption of polysaccharide in body intestine was explored. The results showed that Poria cocos polysaccharide was degraded rapidly and completely in artificial gastric juice within 0.5 h,forming many fragments stable in gastric juice,and almost no degradation in intestinal juice. Poria cocos polysaccharide were mainly absorbed in the intestine,and the higher the initial concentration of polysaccharide,the higher the absorption percentage(ρ). In the process of absorption,the absorption rate constant(Ka)of different initial concentrations of polysaccharides increased at first and then decreased. When absorbed to 120 min,the absorption percentage of the gastrointestinal degradation solution with initial polysaccharide concentration of 0.1004,0.5007 and 1.0004 mg/mL reached(23.52%±0.57%),(49.14%±0.87%)and(57.56%±0.22%),respectively. The study showed that Poria cocos polysaccharide were mainly degraded in gastric juice and absorbed in body intestine in mice.
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