UPLC-Q-Orbitrap HRMS测定白酒接触塑料制品中21种双酚类及其衍生物

建立了超高效液相色谱/四极杆-静电场轨道阱高分辨质谱法（UPLC-Q-Orbitrap HRMS）测定白酒接触塑料制品中21种双酚类及其衍生物的筛查定量方法。迁移后模拟液用甲醇稀释10倍，采用C₁₈色谱柱，以甲醇?5 mmol/L乙酸铵水溶液为流动相进行梯度洗脱，21种目标物在质量浓度范围2.5～500.0 μg/L范围内线性良好，R2大于0.9965，方法定量限为6.0～36.3 μg /L，回收率为82.3%～106.4%，RSD为0.7%～5.2%之间。该方法种类覆盖广，灵敏度高，准确性好，应用于实际样品检测时重复性良好，可为白酒生产过程中此类化合物的风险监测提供技术支撑。

Simultaneous Determination of 21 Bisphenol and Bisphenol Derivatives in Baijiu Contact Plastic Materials by UPLC-Q-Orbitrap High Resolution Mass Spectrometry

A method was developed for the simultaneous determination of 21 bisphenol and bisphenol derivatives in Baijiu contact plastic materials by ultra high performance liquid chromatography-high resolution mass spectrometry.The simulation solution was diluted 10 times with methanol.The compounds were separated on a C18 chromatographic column with the gradient elution of water(contain 5 mmol/L ammonium)and methanol as mobile phase.The result showed that the limits of quantification were in the range of 2.5~500.0μg/L,and the correlation coefficients(R2)of 21 target compounds were higher than 0.9965.The average spiked recoveries were in the range of 82.3%~106.4%,and the relative standard deviations(RSD)were in the range of 0.7%~5.2%.This method was simple,rapid,sensitive,accurate,and could be used for the monitoring of 21 bisphenol and bisphenol diglycidyl ethers in Baijiu and Baijiu contact plastic materials.