植物多肽类胰蛋白酶抑制剂降糖功效研究进展

植物多肽类胰蛋白酶抑制剂（Trypsin inhibitor，TI）作为一种丝氨酸蛋白酶抑制剂具有广泛的生物学活性，参与了降糖、抗癌、抗炎、抗病、抗虫等多方面的生物学过程，在食品科技、医学、农业等多个领域具有重要的用途。其中，对于TI降糖活性的研究，目前虽有学者进行了部分动物实验，但缺乏分子靶标以及分子机制研究，国内外对TI降糖作用机理的认识仍处于起步阶段。本文围绕胰蛋白酶抑制剂在降糖方面的作用及其研究进展进行了总结，重点分析了分子靶标是α-葡萄糖苷酶的降糖机制，并对胰蛋白酶抑制剂降糖功效的应用与开发提出了展望，为今后深入研究胰蛋白酶抑制剂的降糖机理提供理论参考。

Recent Progress in Hypoglycemic Effect of Plant Protein Trypsin Inhibitors

Plant peptide trypsin inhibitors(TI), as serine protease inhibitors, have a wide range of biological activities involved in many biological processes, such as hypoglycemic, anti-cancer, anti-inflammatory, disease-resistant, insect-resistant and so on, which possess important applications in food science and technology, medicine, agriculture and other fields. However, for its hypoglycemic activity, although there are some sporadic animal experiments, due to the lack of corresponding molecular targets and mechanism studies, the mechanisms of TI on hypoglycemic effect are still in the primary stage. This review summarizes the research progress of TI in the mechanism of hypoglycemic activity, focusing on the α-glucosidase as a molecular target, and prospects for the application and development of TI on hypoglycemic effect, which provides theoretical reference for future research on the hypoglycemic mechanism of trypsin inhibitor.