泡面桶中壬基酚总迁移量测定及风险分析

建立了高效液相色谱串联质谱法测定泡面桶中总壬基酚迁移量的分析方法，并对市售泡面桶中壬基酚迁移进行了风险分析与评估。优化了色谱分离条件和固相萃取条件，线性范围1~500 μg/L内线性关系良好，壬基酚的方法检出限为0.002~0.004 μg/L，对实际样品迁移液进行加标回收试验，回收率在79.8%~105.2%之间，相对标准偏差（Relative Standard Deviation，RSDs）在1.74%~9.88%之间。应用该方法对市售54批泡面桶中壬基酚总迁移量进行测定，其中45件样品的迁移液中检出了壬基酚，壬基酚含量在0.006~0.079 μg/L。根据检测结果对市售泡面桶中壬基酚的安全性进行了风险分析，壬基酚的最大每日摄入量为0.0237 μg/d，远低于壬基酚的健康指导值3 μg/d，说明市场上泡面桶相对比较安全，对人体健康存在较低风险。

Determination and Risk Analysis of Nonylphenol Migration in Instant Noodle Barrel

A method was established for the detection of nonylphenol migration in instant noodle barrel by high performance liquid chromatography tandem mass spectrometry (HPLC/MS/MS). Using this method, we conduct risk analysis and assessment to marketed instant noodle barrels. The chromatographic separation and solid phase extraction conditions were optimized. The calibration curves of the nonylphenol showed good linear relationship in the range of 1~500 μg/L. The limits of detection ranged from 0.002~0.004 μg/L. The recoveries of real samples migration fluid at different spiked levels were in the range of 79.8%~105.2%, and the relative standard deviations (RSDs) were 1.74%~9.88%. 54 batches commercial instant noodle barrel were determined with this method, 45 samples detected nonylphenol, and nonylphenol content was 0.006~0.079 μg/L. According to the test results, the safety of nonyphenol in the instant noodle barrel was analyzed. The maximum daily intake of nonyphenol was 0.0237 μg/d, which was far lower than the health guidance value of nonyphenol (3 μg/d), indicating that the instant noodle barrel in the market is relatively safe and has a low risk to human health.