|
|||||
|
|
| 4-（1-甲基胍基）丁酸的合成、表征和抑菌活性 | |
| 引用本文： | 郭睿,韦鹏,来肖,孙江,郭云霞,龙显军. 4-（1-甲基胍基）丁酸的合成、表征和抑菌活性[J]. 食品工业科技, 2011, 0(9): 87-89 |
| 作者姓名： | 郭睿 韦鹏 来肖 孙江 郭云霞 龙显军 |
| 作者单位： | 1. 陕西科技大学教育部轻化工助剂化学与技术重点实验室,陕西西安,710021 2. 陕西科技大学生命科学与工程学院,陕西西安,710021 3. 中化近代环保化工（西安）有限公司,陕西西安,710201 |
| 摘 要： | 以硫脲为原料,经过两步反应合成三氧化硫脲（3）;以N-甲基吡咯烷酮为原料,在HCl10%条件下水解生成4-甲基氨基丁酸盐酸盐（5）;化合物（3）和（5）的亲核取代反应生成目标产物4-（1-甲基胍基）丁酸（6）。各中间体及目标产物结构经过红外光谱、核磁表征,结果表明,成功实现了目标产物的合成。抑菌实验表明,4-（1-甲基胍基）丁酸对金黄色葡萄球菌、大肠杆菌、啤酒酵母菌、黑曲霉的最低抑菌浓度分别为0.19%、0.195%、0.2%、0.19%。 |
| 关 键 词： | 4-(1-甲基胍基)丁酸 合成 表征 抑菌活性 |
Synthesis,characterization and bacteriostatic activity of 4-methylguanidine butyric acid |
|
| GUO Rui,ZHAOYan-yan,WEI Peng,LAI Xiao,SUN Jiang,GUO Yun-xia,LONG Xian-junCo.,Ltd,Xi'an ,China). Synthesis,characterization and bacteriostatic activity of 4-methylguanidine butyric acid[J]. Science and Technology of Food Industry, 2011, 0(9): 87-89 | |
| Authors: | GUO Rui ZHAOYan-yan WEI Peng LAI Xiao SUN Jiang GUO Yun-xia LONG Xian-junCo. Ltd Xi'an China) |
| Affiliation: | GUO Rui1,ZHAOYan-yan1*,WEI Peng1,LAI Xiao1,SUN Jiang1,GUO Yun-xia2,LONG Xian-jun3(1. Key Laboratory of Auxiliary Chemistry and Technology in Light Industry,Ministry of Education,Shaanxi University of Science & Technology,Xi'an 710021,China,2. College of Life Science & Engineering,3. Sinchem Modern Environmental Protection Chemicals(Xi'an)Co.,Ltd,Xi'an 710201,China) |
| Abstract: | Thiourea trioxide(3)was synthesized from thiourea and hydrogen peroxide.4-(methylamino)butanoic acid salts(5)was synthesized from N-methylpyrrolidone in HCl 10%.Compounds(3) reacted with(5) followed by nucleophilic substitution to afford target molecule(6).All intermediates and target molecules were characterized by means of FTIR,NMR.In conclusion,a simple synthetic route had been developed and target molecule had been successfully synthesized,The antibacterial tests showed that 4-methylguanidine butyric ac... |
| Keywords: | 4-methylguanidine butyric acid synthesis characterization bacteriostatic activity |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |