基于环糊精及其衍生物的递送体系在食品领域的研究进展

利用环糊精及其衍生物无毒害、无气味等特性，包埋水溶性差、且对光照、温度、pH等敏感的活性成分，起到提高水溶性、增强稳定性、掩蔽不良气味等作用，并且可以达到靶向释放活性成分的目的。本文综述了近几年国内外关于环糊精包埋活性成分递送体系的研究，首先介绍了几种基于环糊精及其衍生物的递送体系，包括包合物、水凝胶和Pickering乳液，其中重点讨论了包合物的常用制备方法，即共沉淀法、超声法、研磨法、冷冻干燥法和喷雾干燥法的优缺点及适用范围；然后总结了环糊精及其衍生物递送体系对食品领域中抗菌剂、抗氧化剂、以及维生素、蛋白质等活性成分的保护和递送；最后，对环糊精递送体系在食品领域的研究和应用进行展望，为后续研究提供参考资料。

Recent Progress of Delivery Systems Based on Cyclodextrin and Its Derivatives in Food Industry

Taking advantages of nontoxicity and odorlessness, cyclodextrin and its derivatives can encapsulate some bioactive substances with poor water solubility and sensitivity to light, temperature, and pH, thus to enhance their aqueous solubility and stability, mask bad odor, and also targeted release them. This paper reviews recent researches on cyclodextrin-based delivery systems for carrying active substances. Firstly, several delivery systems based on cyclodextrin and its derivatives are introduced, including inclusion complexes, hydrogels, and Pickering emulsions. In this part, the advantages and drawbacks as well as the scope of applications of several common preparation methods of inclusion complex, i.e., coprecipitation method, ultrasonic method, grinding method, freeze-drying method and spray-drying method are detailed described and discussed. Then, the protection and delivery of cyclodextrin-based delivery systems to antibacterial agents, antioxidants, vitamins, proteins and other active ingredients in food industry are summarized. Finally, further research and application of cyclodextrin-based delivery systems in food industry are prospected, which would provide a theoretical basis for subsequent research.