铁皮石斛多糖分离纯化及其药理活性研究进展

铁皮石斛是我国名贵的药食同源资源，具有较高的保健价值。铁皮石斛多糖是铁皮石斛中重要的活性成分之一。本文对铁皮石斛多糖的提取、分离纯化、分子量、单糖组成进行总结归纳，并对铁皮石斛多糖的降血糖及改善糖尿病并发症、保护胃黏膜损伤、抗肿瘤、调节微生态的最新研究进展进行综述。针对目前铁皮石斛多糖含量影响因素较多、分离纯化重复性差、结构分析不够清晰、构效关系的研究不够深入等现状，提出未来研究的展望，以期为铁皮石斛的开发利用提供有益参考。

Research Progress on Isolation,Purification and Pharmacological Activities of Dendrobium officinale Polysaccharide

Dendrobium officinale is a valuable homologous resource of medicine and food in China, which has rich health value. Dendrobium officinale polysaccharide is one of the important active ingredients in Dendrobium officinale. Therefore, research on development of the extraction, separation and purification, composition of monosaccharides, molecular weight of Dendrobium officinale polysaccharides are summarized in this review, and the effect of lowering blood sugar and improving diabetic complications, protecting of gastric mucosal injury, anti-tumor, regulating microecology are also discussed. In view of the current situation of polysaccharide content affected by many factors, poor repeatability of separation and purification, unclear structure analysis, and less in-depth structure-activity relationship of Dendrobium officinale, the future research views of Dendrobium officinale polysaccharides are put forward in order to provide useful reference for the development and utilization of Dendrobium officinale.