| 泽泻提取物对α-葡萄糖苷酶抑制活性的研究 |
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| 引用本文： | 易醒,仲秋晨,焦爽,张建平,肖小年.泽泻提取物对α-葡萄糖苷酶抑制活性的研究[J].食品与发酵工业,2011,37(5). |
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| 作者姓名： | 易醒 仲秋晨 焦爽 张建平 肖小年 |
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| 作者单位： | 1. 南昌大学中德食品工程中心,江西南昌,330047
2. 南昌大学中德联合研究院,江西南昌,330047 |
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| 基金项目： | 国家自然科学基金项目(31060216); 江西省自然科学基金项目(2007GZY2015); 江西省教育厅科学技术研究项目(GJJ09077) |
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| 摘 要： | 将泽泻水提取物依次用石油醚、乙酸乙酯、正丁醇萃取,萃取后的水相过大孔树脂柱得到水洗脱部分和95%乙醇洗脱部分,然后测定各部分的酶抑制活性,对高活性部分进行酶抑制动力学研究。结果显示,正丁醇萃取部分的抑制活性最高,α-葡萄糖苷酶抑制率达92.30%,高于阳性对照阿卡波糖。正丁醇萃取部分的抑制作用属非竞争性抑制。
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| 关 键 词： | 泽泻 提取物 α-葡萄糖苷酶 抑制作用 糖尿病 |
Study on the a-glucosidase Inhibitor from Alisma orientalis |
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| Yi Xing,Zhong Qiu-chen,Jiao Shuang,Zhang Jian-ping,Xiao Xiao-nian.Study on the a-glucosidase Inhibitor from Alisma orientalis[J].Food and Fermentation Industries,2011,37(5). |
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| Authors: | Yi Xing Zhong Qiu-chen Jiao Shuang Zhang Jian-ping Xiao Xiao-nian |
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| Affiliation: | Yi Xing1,Zhong Qiu-chen1,Jiao Shuang1,Zhang Jian-ping1,Xiao Xiao-nian2 1(Sino-Gerrman Food Engineering Center,Nanchang University,Nanchang 330047,China) 2(Sino-German Joint Research Institute,China) |
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| Abstract: | The sequential extractions using petroleum ether,ethyl acetate and n-butanol were applied to water extract of Alisma orientale.The aqueous phase was added on a column of macroporous resin and was washed with distilled water and 95%ethanol,successively.In addition,the inhibitory activity against α-glucosidase of each fraction was determined and the inhibitory kinetics of the fraction with the strongest inhibitory activities was investigated.The results showed that the fraction with the strongest inhibitory activities was n-butanol fraction,a kind of non-competition inhibitor with inhibitory ratio of 92.30%. |
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| Keywords: | Alisma orientalis extract α-glucosidase inhibition diabetes mellitus |
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